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Comparing the Efficacy of Two Cognitive Screening Tools in Identifying Gray and White Matter Brain Damage among Older Adults.
Andreatta Maduro, Paula; Guimarães, Manoel Pereira; de Sousa Rodrigues, Mateus; Pereira Rolim Coimbra Pinto, Ana Paula; da Mota Junior, Américo Alves; Lima Rocha, Alaine Souza; Matoso, Juliana Magalhães Duarte; Bavaresco Gambassi, Bruno; Schwingel, Paulo Adriano.
Afiliação
  • Andreatta Maduro P; Post-Graduation Program in Health Sciences (PPGCS), University of Pernambuco (UPE), Recife, PE 50100-130, Brazil.
  • Guimarães MP; Human Performance Research Laboratory (LAPEDH), UPE, Petrolina, PE 56328-900, Brazil.
  • de Sousa Rodrigues M; University Hospital of the Federal University of Vale do São Francisco (HU-UNIVASF), Brazilian Hospital Services Company (EBSERH), Petrolina, PE 56304-205, Brazil.
  • Pereira Rolim Coimbra Pinto AP; Human Performance Research Laboratory (LAPEDH), UPE, Petrolina, PE 56328-900, Brazil.
  • da Mota Junior AA; Human Performance Research Laboratory (LAPEDH), UPE, Petrolina, PE 56328-900, Brazil.
  • Lima Rocha AS; University Hospital of the Federal University of Vale do São Francisco (HU-UNIVASF), Brazilian Hospital Services Company (EBSERH), Petrolina, PE 56304-205, Brazil.
  • Matoso JMD; University Hospital of the Federal University of Vale do São Francisco (HU-UNIVASF), Brazilian Hospital Services Company (EBSERH), Petrolina, PE 56304-205, Brazil.
  • Bavaresco Gambassi B; Human Performance Research Laboratory (LAPEDH), UPE, Petrolina, PE 56328-900, Brazil.
  • Schwingel PA; University Hospital of the Federal University of Vale do São Francisco (HU-UNIVASF), Brazilian Hospital Services Company (EBSERH), Petrolina, PE 56304-205, Brazil.
J Aging Res ; 2024: 5527225, 2024.
Article em En | MEDLINE | ID: mdl-38690079
ABSTRACT

Background:

Ageing is associated with structural changes in brain regions and functional decline in cognitive domains. Noninvasive tools for identifying structural damage in the brains of older adults are relevant for early treatment.

Aims:

This study aims to evaluate and compare the accuracy of the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA©) in identifying gray and white matter brain damage in older individuals with varying degrees of cognitive impairment.

Methods:

Ninety older adults (62 women) with an average age of 69 ± 7 years were enrolled and categorized as having no cognitive impairment (NCI), mild cognitive impairment (MCI), or moderate cognitive impairment (MoCI). Magnetic resonance imaging (MRI) was utilized to assess the number, volume, and distribution of brain damage. The Fazekas and Scheltens scales were applied to the brain MRIs, and inferential statistics were employed to compare variables among the groups.

Results:

Cognitive impairment was observed in 56.7% of the participants (95% confidence interval (CI) 46.4-66.4%), with thirty-six older adults (40%) classified as MCI and 15 (17%) as MoCI. Cognitive impairment and medial temporal lobe (MTL) atrophy were found to be associated (p=0.001), exhibiting higher mean volume scales of the MTL atrophied area in the MoCI group (p < 0.001). The MMSE accurately revealed MTL atrophy based on the Scheltens (p < 0.05) and Fazekas (p < 0.05) scales. At the same time, the MoCA accurately identified periventricular white matter (PWM) abnormalities according to the Fazekas scale (p < 0.05).

Conclusions:

The MMSE and MoCA screening tools effectively identified gray and white matter brain damage in older adults with varying degrees of cognitive impairment. Lower MMSE scores are associated with MTL atrophy and lesions, and lower MoCA scores are related to PWM lesions. The concurrent use of MMSE and MoCA is recommended for assessing structural changes in distinct brain regions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Aging Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Aging Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos