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Synthesis, Characterization, and Evaluation of the Antimicrobial Effects and Cytotoxicity of a Novel Nanocomposite Based on Polyamide 6 and Trimetaphosphate Nanoparticles Decorated with Silver Nanoparticles.
de Morais, Leonardo Antônio; Souza Neto, Francisco Nunes de; Hosida, Thayse Yumi; Dos Santos, Danilo Martins; de Almeida, Bianca Carvalho; Frollini, Elisabete; Filho, Sergio Paulo Campana; Barbosa, Debora de Barros; de Camargo, Emerson Rodrigues; Delbem, Alberto Carlos Botazzo.
Afiliação
  • de Morais LA; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil.
  • Souza Neto FN; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil.
  • Hosida TY; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil.
  • Dos Santos DM; Sao Carlos Institute of Chemistry, University of Sao Paulo, Av. Trabalhador Sao-Carlense, 400, São Carlos 13566-590, São Paulo, Brazil.
  • de Almeida BC; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil.
  • Frollini E; Sao Carlos Institute of Chemistry, University of Sao Paulo, Av. Trabalhador Sao-Carlense, 400, São Carlos 13566-590, São Paulo, Brazil.
  • Filho SPC; Sao Carlos Institute of Chemistry, University of Sao Paulo, Av. Trabalhador Sao-Carlense, 400, São Carlos 13566-590, São Paulo, Brazil.
  • Barbosa DB; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil.
  • de Camargo ER; Center for Exact Sciences and Technology, Federal University of São Carlos (UFSCAR), Av. Trab. São Carlense, 400, São Carlos 13566-590, São Paulo, Brazil.
  • Delbem ACB; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba 16015-050, São Paulo, Brazil.
Antibiotics (Basel) ; 13(4)2024 Apr 08.
Article em En | MEDLINE | ID: mdl-38667015
ABSTRACT
This study aimed to develop a polymeric matrix of polyamide-6 (P6) impregnated with trimetaphosphate (TMP) nanoparticles and silver nanoparticles (AgNPs), and to evaluate its antimicrobial activity, surface free energy, TMP and Ag+ release, and cytotoxicity for use as a support in dental tissue. The data were subjected to statistical analysis (p < 0.05). P6 can be incorporated into TMP without altering its properties. In the first three hours, Ag+ was released for all groups decorated with AgNPs, and for TMP, the release only occurred for the P6-TMP-5% and P6-TMP-10% groups. In the inhibition zones, the AgNPs showed activity against both microorganisms. The P6-TMP-2.5%-Ag and P6-TMP-5%-Ag groups with AgNPs showed a greater reduction in CFU for S. mutans. For C. albicans, all groups showed a reduction in CFU. The P6-TMP groups showed higher cell viability, regardless of time (p < 0.05). The developed P6 polymeric matrix impregnated with TMP and AgNPs demonstrated promising antimicrobial properties against the tested microorganisms, making it a potential material for applications in scaffolds in dental tissues.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Antibiotics (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Antibiotics (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça