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Efficacy of melatonin in decreasing the incidence of delirium in critically ill adults: a randomized controlled trial.
Bandyopadhyay, Anjishnujit; Yaddanapudi, Lakshmi Narayana; Saini, Vikas; Sahni, Neeru; Grover, Sandeep; Puri, Sunaakshi; Ashok, Vighnesh.
Afiliação
  • Bandyopadhyay A; Department of Anaesthesiology, Pain Medicine and Critical Care, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences - New Delhi, India.
  • Yaddanapudi LN; Department of Anaesthesia and Intensive Care, Level 4, Nehru Hospital, Postgraduate Institute of Medical Education and Research, Sector 12 - Chandigarh, India.
  • Saini V; Department of Anaesthesia and Intensive Care, Level 4, Nehru Hospital, Postgraduate Institute of Medical Education and Research, Sector 12 - Chandigarh, India.
  • Sahni N; Department of Anaesthesia and Intensive Care, Level 4, Nehru Hospital, Postgraduate Institute of Medical Education and Research, Sector 12 - Chandigarh, India.
  • Grover S; Department of Psychiatry, Nehru Hospital, Postgraduate Institute of Medical Education and Research, Sector 12 - Chandigarh, India.
  • Puri S; Department of Anaesthesia and Intensive Care, Level 4, Nehru Hospital, Postgraduate Institute of Medical Education and Research, Sector 12 - Chandigarh, India.
  • Ashok V; Department of Anaesthesia and Intensive Care, Level 4, Nehru Hospital, Postgraduate Institute of Medical Education and Research, Sector 12 - Chandigarh, India.
Crit Care Sci ; 36: e20240144en, 2024.
Article em En, Pt | MEDLINE | ID: mdl-38656078
ABSTRACT

OBJECTIVE:

To determine whether enteral melatonin decreases the incidence of delirium in critically ill adults.

METHODS:

In this randomized controlled trial, adults were admitted to the intensive care unit and received either usual standard care alone (Control Group) or in combination with 3mg of enteral melatonin once a day at 9 PM (Melatonin Group). Concealment of allocation was done by serially numbered opaque sealed envelopes. The intensivist assessing delirium and the investigator performing the data analysis were blinded to the group allocation. The primary outcome was the incidence of delirium within 24 hours of the intensive care unit stay. The secondary outcomes were the incidence of delirium on Days 3 and 7, intensive care unit mortality, length of intensive care unit stay, duration of mechanical ventilation and Glasgow outcome score (at discharge).

RESULTS:

We included 108 patients in the final analysis, with 54 patients in each group. At 24 hours of intensive care unit stay, there was no difference in the incidence of delirium between Melatonin and Control Groups (29.6 versus 46.2%; RR = 0.6; 95%CI 0.38 - 1.05; p = 0.11). No secondary outcome showed a statistically significant difference.

CONCLUSION:

Enteral melatonin 3mg is not more effective at decreasing the incidence of delirium than standard care is in critically ill adults.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Terminal / Delírio / Unidades de Terapia Intensiva / Melatonina Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En / Pt Revista: Crit Care Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Terminal / Delírio / Unidades de Terapia Intensiva / Melatonina Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En / Pt Revista: Crit Care Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil