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Chitosan-graphene quantum dot based active film as smart wound dressing.
Ribeiro, Elisabete Regina Fernandes Ramos; Correa, Luana Barbosa; Ricci-Junior, Eduardo; Souza, Pedro Filho Noronha; Dos Santos, Clenilton Costa; de Menezes, Alan Silva; Rosas, Elaine Cruz; Bhattarai, Prapanna; Attia, Mohamed F; Zhu, Lin; Alencar, Luciana Magalhães Rebelo; Santos-Oliveira, Ralph.
Afiliação
  • Ribeiro ERFR; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, 21941906, Brazil.
  • Correa LB; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, 21941906, Brazil.
  • Ricci-Junior E; Federal University of Rio de Janeiro, School of Pharmacy, Galenic Development Laboratory (LADEG), Rio de Janeiro, 21941-170, Brazil.
  • Souza PFN; Biochemistry and Molecular Biology Department, Federal University of Ceará, CE, Brazil, Laboratory of Plant Defense Proteins, Ceará, 60451, Brazil.
  • Dos Santos CC; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal, University of Ceará, 60451, Brazil.
  • de Menezes AS; Federal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranháo, 65080-805, Brazil.
  • Rosas EC; Federal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranháo, 65080-805, Brazil.
  • Bhattarai P; National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Oswaldo Cruz Foundation, Rio de Janeiro, 21041361, Brazil.
  • Attia MF; Laboratory of Applied Pharmacology, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, 21041361, Brazil.
  • Zhu L; Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, 77843, USA.
  • Alencar LMR; Center for Nanotechnology in Drug Delivery and Division of Pharmaco-engineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Santos-Oliveira R; Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, 77843, USA.
J Drug Deliv Sci Technol ; 802023 Feb.
Article em En | MEDLINE | ID: mdl-38650740
ABSTRACT
Graphene quantum dots (GQDs), are biocompatible materials, with mechanical strength and stability. Chitosan, has antibacterial and anti-inflammatory properties, and biocompatibility. Wound healing is a challenging process especially in chronic diseases and infection. In this study, films consisting of chitosan and graphene quantum dots were developed for application in infected wounds. The chitosan-graphene films were prepared in the acidic solution followed by slow solvent evaporation and drying. The chitosan-graphene films were characterized by the scanning electron microscopy, x-ray diffraction, atomic force microscopy, Raman spectroscopy and thermogravimetric analysis. The films' was evaluated by the wound healing assays, hemolytic potential, and nitrite production, cytokine production and swelling potential. The obtained films were flexible and well-structured, promoting cell migration, greater antibacterial activity, lower hemolytic activity, and maintaining wound moisture. Our data suggested that the use of graphene quantum dot-containing chitosan films would be an efficient and promising way in combating wounds.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Drug Deliv Sci Technol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Drug Deliv Sci Technol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: França