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Comparison of the Secondary Metabolism of the Basidiomycetes Armillaria mellea and Desarmillaria ectypa.
Chepkemoi, Jacklyne; Pfütze, Sebastian; Kimani, Njogu M; Matasyoh, Josphat C; Stadler, Marc.
Afiliação
  • Chepkemoi J; Department of Chemistry, Faculty of Sciences, Egerton University, P.O. Box 536, 20115, Egerton, Kenya.
  • Pfütze S; Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Inhoffenstrasse 7, 38124, Braunschweig, Germany.
  • Kimani NM; Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Inhoffenstrasse 7, 38124, Braunschweig, Germany.
  • Matasyoh JC; Department of Physical Sciences, University of Embu, Embu, 6-60100, Kenya.
  • Stadler M; Department of Chemistry, Faculty of Sciences, Egerton University, P.O. Box 536, 20115, Egerton, Kenya.
Chem Biodivers ; 21(7): e202400933, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38640089
ABSTRACT
During the course of our ongoing studies on the secondary metabolism of cultures of Basidiomycota, a new meroterpenoid named 10, 15-dihydroxydihydromelleolide (1) was isolated along with the known armillaridin (2) and arnamiol (3) from cultures of the rare saprotrophic species, Desarmillaria ectypa. These are the first secondary metabolites that were ever isolated from the latter species. A concurrently studied strain of the common pathogenic A. mellea yielded other melleolides, with 5'-O-methylmelledonal (4), melledonal C (5), 10 α-hydroxydihydromelleolide (6) and melledonal (7). The chemical structures were elucidated using 1D and 2D NMR spectroscopy and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). All compounds were studied for their antimicrobial and cytotoxic effects against a panel of microbes and mammalian cell lines, and the results are also reported.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Sensibilidade Microbiana / Armillaria / Metabolismo Secundário Limite: Animals / Humans Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Quênia País de publicação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Sensibilidade Microbiana / Armillaria / Metabolismo Secundário Limite: Animals / Humans Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Quênia País de publicação: Suíça