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Type 1 Diabetes Brazilian patients exhibit reduced frequency of recent thymic emigrants in regulatory CD4+CD25+Foxp3+T cells.
Nogueira, Jeane de Souza; Gomes, Thamires Rodrigues; Secco, Danielle Angst; de Almeida, Inez Silva; da Costa, Alessandra Saldanha Matheus Fernandes; Cobas, Roberta Arnoldi; Costa Dos Santos, Gilson; Gomes, Marília Brito; Porto, Luís Cristóvão.
Afiliação
  • Nogueira JS; Immunogenetic and Histocompatibility Laboratory (HLA-UERJ), Technologic core in Tissue Repair and Histocompatibility (TIXUS), Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Gomes TR; Immunogenetic and Histocompatibility Laboratory (HLA-UERJ), Technologic core in Tissue Repair and Histocompatibility (TIXUS), Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Secco DA; Immunogenetic and Histocompatibility Laboratory (HLA-UERJ), Technologic core in Tissue Repair and Histocompatibility (TIXUS), Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • de Almeida IS; Nursing Faculty, Department of Nursing Fundamentals, Ambulatory of the Adolescent Health Studies Center (NESA), Pedro Ernesto University Hospital, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • da Costa ASMF; Ambulatory of Diabetes, Piquet Carneiro Polyclinic, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Cobas RA; Ambulatory of Diabetes, Piquet Carneiro Polyclinic, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Costa Dos Santos G; Laboratory of Metabolomics (LabMet), IBRAG, Rio de Janeiro State University, Rio de Janeiro RJ Brazil.
  • Gomes MB; Ambulatory of Diabetes, Piquet Carneiro Polyclinic, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Porto LC; Immunogenetic and Histocompatibility Laboratory (HLA-UERJ), Technologic core in Tissue Repair and Histocompatibility (TIXUS), Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: luis.cristovaoporto@gmail.com.
Immunol Lett ; 267: 106857, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38604551
ABSTRACT
To control immune responses, regulatory CD4+CD25+Foxp3+ T cells (Treg) maintain their wide and diverse repertoire through continuous arrival of recent thymic emigrants (RTE). However, during puberty, the activity of RTE starts to decline as a natural process of thymic involution, introducing consequences, not completely described, to the repertoire. Type 1 diabetes (T1D) patients show quantitative and qualitative impairments on the Treg cells. Our aim was to evaluate peripheral Treg and RTE cell frequencies, in T1D patients from two distinct age groups (young and adults) and verify if HLA phenotypes are concomitant associated. To this, blood samples from Brazilian twenty established T1D patients (12 young and 8 adults) and twenty-one healthy controls (11 young and 10 adults) were analyzed, by flow cytometry, to verify the percentages of CD4, Treg (CD4+CD25+Foxp3+) and the subsets of CD45RA+ (naive) and CD31+(RTE) within then. Furthermore, the HLA typing was also set. We observed that the young established T1D patients feature decreased frequencies in total Treg cells and naive RTE within Treg cells. Significant prevalence of HLA alleles, associated with risk, in T1D patients, was also identified. Performing a multivariate analysis, we confirmed that the cellular changes described offers significant variables that distinct T1D patients from the controls. Our data collectively highlight relevant aspects about homeostasis imbalances in the Treg cells of T1D patients, especially in young, and disease prognosis; that might contribute for future therapeutic strategies involving Treg cells manipulation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timo / Linfócitos T Reguladores / Diabetes Mellitus Tipo 1 / Fatores de Transcrição Forkhead / Subunidade alfa de Receptor de Interleucina-2 Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Immunol Lett Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timo / Linfócitos T Reguladores / Diabetes Mellitus Tipo 1 / Fatores de Transcrição Forkhead / Subunidade alfa de Receptor de Interleucina-2 Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Immunol Lett Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda