Ironing out obesity.

de Souza, Gabriel O; Dos Santos, Willian O; Donato, Jose

de Souza, Gabriel O; Dos Santos, Willian O; Donato, Jose.

Afiliação

de Souza GO; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.
Dos Santos WO; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.
Donato J; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil. Electronic address: jdonato@icb.usp.br.

Trends Endocrinol Metab ; 35(6): 456-458, 2024 Jun.

Article em En | MEDLINE | ID: mdl-38599900

ABSTRACT

ABSTRACT

Obesity is associated with dysfunctions in hypothalamic neurons that regulate metabolism, including agouti-related protein (AgRP)-expressing neurons. In a recent article, Zhang et al. demonstrated that either diet- or genetically induced obesity promoted iron accumulation specifically in AgRP neurons. Preventing iron overload in AgRP neurons mitigated diet-induced obesity and related comorbidities in male mice.

Assuntos

Proteína Relacionada com Agouti; Ferro; Obesidade; Obesidade/metabolismo; Animais; Humanos; Ferro/metabolismo; Proteína Relacionada com Agouti/metabolismo; Camundongos; Neurônios/metabolismo; Masculino; Hipotálamo/metabolismo; Sobrecarga de Ferro/metabolismo

Palavras-chave

hypothalamus; insulin resistance; iron; leptin resistance; obesity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Relacionada com Agouti / Ferro / Obesidade Limite: Animals / Humans / Male Idioma: En Revista: Trends Endocrinol Metab Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

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