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Sociodemographic and clinical characteristics associated with maternal and congenital syphilis - A prospective study in Peru.
Carcamo, Cesar P; Velasquez, Carlos; Rocha, Sandra C; Centurion-Lara, Arturo; Lopez-Torres, Lorena; Parveen, Nikhat.
Afiliação
  • Carcamo CP; School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru. Electronic address: cesar.carcamo@upch.pe.
  • Velasquez C; Instituto Nacional Materno Perinatal, Lima, Peru.
  • Rocha SC; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, USA.
  • Centurion-Lara A; School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Lopez-Torres L; School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Parveen N; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, USA. Electronic address: parveeni@njms.rutgers.edu.
Int J Infect Dis ; 143: 107041, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38583824
ABSTRACT

OBJECTIVES:

The objective of this study was to explore the factors and outcomes associated with gestational syphilis in Peru.

METHODS:

Women from the miscarriage, vaginal delivery, and C-section wards from a large maternity hospital in Lima with or without syphilis diagnosis were enrolled and their pregnancy outcomes compared. Maternal syphilis status using maternal blood and child serostatus using cord blood were determined by rapid plasma reagin (RPR) and rapid syphilis tests. The newborns' clinical records were used to determine congenital syphilis.

RESULTS:

A total of 340 women were enrolled, 197 were positive and 143 were negative for RPR/rapid syphilis tests. Antibody titers in sera from cord and maternal blood were comparable with RPR titers and were highly correlated (rho = 0.82, P <0.001). Young age (P = 0.009) and lower birth weight (P = 0.029) were associated with gestational syphilis. Of the women with gestational syphilis, 76% had received proper treatment. Mothers of all newborns with congenital syphilis also received appropriate treatment. Treatment of their sexual partners was not documented.

CONCLUSIONS:

Syphilis during pregnancy remains a major cause of the fetal loss and devastating effects of congenital syphilis in newborns.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Sífilis Congênita / Sífilis Limite: Adolescent / Adult / Female / Humans / Newborn / Pregnancy País/Região como assunto: America do sul / Peru Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2024 Tipo de documento: Article País de publicação: Canadá
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Sífilis Congênita / Sífilis Limite: Adolescent / Adult / Female / Humans / Newborn / Pregnancy País/Região como assunto: America do sul / Peru Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2024 Tipo de documento: Article País de publicação: Canadá