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Patients who received sleeve gastrectomy have lower plasma osteopontin levels than those who did not.
Öztürk, Dogan; Koca, Arzu Or; Keskin, Müge; Öztürk, Bülent; Oguz, Esra Firat; Turhan, Turan; Bulus, Hakan.
Afiliação
  • Öztürk D; University of Health Sciences, Ankara Atatürk Sanatoryum Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Electronic address: drdoganozturk@hotmail.com.
  • Koca AO; University of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Onkoloji Education and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey.
  • Keskin M; University of Health Sciences, Ankara City Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey.
  • Öztürk B; University of Health Sciences, Ankara Atatürk Sanatoryum Education and Research Hospital, Department of General Surgery, Ankara, Turkey.
  • Oguz EF; University of Health Sciences, Ankara City Hospital, Department of Medical Biochemistry, Ankara, Turkey.
  • Turhan T; University of Health Sciences, Ankara City Hospital, Department of Medical Biochemistry, Ankara, Turkey.
  • Bulus H; University of Health Sciences, Ankara Atatürk Sanatoryum Education and Research Hospital, Department of General Surgery, Ankara, Turkey.
Clinics (Sao Paulo) ; 79: 100352, 2024.
Article em En | MEDLINE | ID: mdl-38574573
ABSTRACT

BACKGROUND:

The aim of this study was to compare metabolic parameters, plasma Osteopontin (OPN) and Hepatocyte Growth Factor (HGF) levels between Sleeve Gastrectomy (SG) patients in their 6th post-operation month and healthy control patients.

METHODS:

Height, weight, Body Mass Index (BMI) and laboratory parameters of 58 SG patients aged 18‒65 years (Group 1) and 46 healthy control patients (Group 2) were compared. In addition, preoperative and postoperative sixth-month BMI and laboratory parameters of the patients in Group 1 were compared.

RESULTS:

The mean age and gender distributions of the groups were similar (p > 0.05). Mean BMI was 28.9 kg/m2 in Group 1 and 27 kg/m2 in Group 2 (p < 0.01). While plasma HGF levels were similar between both groups, plasma OPN levels were higher in Group 2 (p < 0.001). Fasting plasma glucose, total cholesterol, triglyceride, fasting plasma insulin and insulin resistance values were higher in Group 1, while alanine aminotransferase and aspartate aminotransferase levels were higher in Group 2 (p < 0.05). There was a strong correlation between plasma HGF and OPN levels in Group 1, but not in Group 2 (Rho = 0.805, p < 0.001).

CONCLUSION:

OPN and HGF are promising biomarkers that can be used to better understand and detect problems related to obesity. The fact that patients in the early post-SG period had lower plasma OPN and similar plasma HGF compared to non-surgical patients of similar age and gender with higher BMI may be another favorable and previously unknown metabolic effect of SG.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Obesidade Mórbida / Resistência à Insulina / Laparoscopia / Diabetes Mellitus Tipo 2 Limite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Obesidade Mórbida / Resistência à Insulina / Laparoscopia / Diabetes Mellitus Tipo 2 Limite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos