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Superior bioavailability of the calcium salt form of ß-hydroxy-ß-methylbutyrate compared with the free acid form.
Ribeiro, Heitor Rodrigues; Jardim, Felipe Gregório; Roldán, Miriam Sanz; de Salles Painelli, Vitor; da Eira Silva, Vinicius; Tritto, Aline Cristina Capparelli; Formalioni, Andressa; Custoias, Giovani Boldrini; Pereira, Wagner Ribeiro; Solis, Marina Yazigi; Carvalho, Felipe; Junior, Ernani Pinto; Artioli, Guilherme Giannini.
Afiliação
  • Ribeiro HR; Applied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
  • Jardim FG; Rheumatology Division, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
  • Roldán MS; Applied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
  • de Salles Painelli V; Rheumatology Division, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
  • da Eira Silva V; Faculdade de Ciências Farmacêuticas, Universidade de São Paulo (USP), São Paulo, Brazil.
  • Tritto ACC; Strength Training Study and Research Group, Institute of Health Sciences, Paulista University UNIP, São Paulo, Brazil.
  • Formalioni A; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.
  • Custoias GB; Applied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
  • Pereira WR; Rheumatology Division, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
  • Solis MY; Applied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
  • Carvalho F; Rheumatology Division, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
  • Junior EP; Applied Physiology & Nutrition Research Group, University of São Paulo, São Paulo, Brazil.
  • Artioli GG; Rheumatology Division, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
Amino Acids ; 56(1): 27, 2024 Apr 02.
Article em En | MEDLINE | ID: mdl-38564019
ABSTRACT
We investigated the bioavailability of the calcium salt (HMB-Ca) and the free acid (HMB-FA) forms of ß-hydroxy-ß-methylbutyrate (HMB). Sixteen young individuals received the following treatments on three different occasions in a counterbalanced crossover fashion (1) HMB-FA in clear capsules; (2) HMB-Ca in gelatine capsules; (3) HMB-Ca dissolved in water. All treatments provided 1 g of HMB. Blood samples were taken before and on multiple time points following ingestion. The following parameters were calculated peak plasma (Cmax), time to peak (Tmax), slope of HMB appearance in blood, area under the curve (AUC), half-life time (t1/2) and relative bioavailability (HMB-Ca in water set as reference). All treatments led to rapid and large increases in plasma HMB. HMB-Ca in capsules and in water showed similar plasma HMB values across time (p = 0.438). HMB-FA resulted in lower concentrations vs. the other treatments (both p < 0.001). AUC (HMB-Ca in capsules 50,078 ± 10,507; HMB-Ca in water 47,871 ± 10,783; HMB-FA 29,130 ± 12,946 µmol L-1 × 720 min), Cmax (HMB-Ca in capsules 229.2 ± 65.9; HMB-Ca in water 249.7 ± 49.7; HMB-FA 139.1 ± 67.2 µmol L-1) and relative bioavailability (HMB-Ca in capsules 104.8 ± 14.9%; HMB-FA 61.5 ± 17.0%) were lower in HMB-FA vs. HMB-Ca (all p < 0.001). HMB-Ca in water resulted in the fastest Tmax (43 ± 22 min) compared to HMB-Ca in capsules (79 ± 40 min) and HMB-FA (78 ± 21 min) (all p < 0.05), while t1/2 was similar between treatments. To conclude, HMB-Ca exhibited superior bioavailability compared to HMB-FA, with HMB-Ca in water showing faster absorption. Elimination kinetics were similar across all forms, suggesting that the pharmaceutical form of HMB affects the absorption rates, but not its distribution or elimination.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Valeratos / Água / Cálcio Limite: Humans Idioma: En Revista: Amino Acids Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Áustria
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Valeratos / Água / Cálcio Limite: Humans Idioma: En Revista: Amino Acids Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Áustria