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Obstetric and neonatal outcomes, antiseizure medication profile, and seizure types in pregnant women in a vulnerability state from Brazil.
Leite, Magnúcia de Lima; Topocov, Tatiana Natasha; de Oliveira, Tales Lyra; Almeida, Daniel Dos Santos; Mota Ortiz, Sandra Regina; da Silva, José Claudio.
Afiliação
  • Leite ML; Universidade Estadual de Ciências da Saúde Alagoas (UNCISAL), Maceió, AL, Brazil.
  • Topocov TN; Universidade de São Paulo (USP), São Paulo, SP, Brazil.
  • de Oliveira TL; Universidade de São Paulo (USP), São Paulo, SP, Brazil.
  • Almeida DDS; Universidade Municipal de São Caetano do Sul (USCS), São Paulo, SP, Brazil.
  • Mota Ortiz SR; Universidade Estadual de Ciências da Saúde Alagoas (UNCISAL), Maceió, AL, Brazil.
  • da Silva JC; Universidade Municipal de São Caetano do Sul (USCS), São Paulo, SP, Brazil.
PLoS One ; 19(4): e0291190, 2024.
Article em En | MEDLINE | ID: mdl-38558080
ABSTRACT
This retrospective cohort study described the obstetric and neonatal outcomes, antiseizure medication (ASM) use, and types of seizures in pregnant women with epilepsy (PWWE). Data collected from the medical records of 224 PWWE aged < 40 years with controlled or refractory seizures and 492 pregnant women without epilepsy (PWNE) control group from high-risk maternity hospitals in Alagoas between 2008 and 2021 were included in this study. The obstetric and neonatal outcomes observed in PWWE were pregnancy-related hypertension (PrH) (18.4%), oligohydramnios (10.3%), stillbirth (6.4%), vaginal bleeding (6%), preeclampsia (4.7%), and polyhydramnios (3%). There was a greater likelihood of PrH in PWWE with generalized tonic-clonic seizures (GTCS) and that of maternal intensive care unit (ICU) admissions in those with GTCS and status epilepticus, and phenytoin and lamotrigine use. PWWE with GTCS had a higher risk of stillbirth and premature delivery. PWWE with status epilepticus were treated with lamotrigine. Phenobarbital (PB) with diazepam were commonly used in GTCS and status epilepticus. Total 14% patients did not use ASM, while 50.2% used monotherapy and 35.8% used polytherapy. Total 60.9% of patients used PB and 25.2% used carbamazepine. This study described the association between the adverse obstetric and neonatal outcomes and severe seizure types in PWWE.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Epiléptico / Epilepsia Limite: Female / Humans / Newborn / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Epiléptico / Epilepsia Limite: Female / Humans / Newborn / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos