Efficacy of deep brain stimulation of the subthalamic nucleus versus globus pallidus internus on sensory complaints.

Ghilardi, Maria Gabriela S; Campos, Ana Carolina P; Cury, Rubens G; Martinez, Raquel C R; Pagano, Rosana L; Fonoff, Erich T

Ghilardi, Maria Gabriela S; Campos, Ana Carolina P; Cury, Rubens G; Martinez, Raquel C R; Pagano, Rosana L; Fonoff, Erich T.

Afiliação

Ghilardi MGS; Division of Functional Neurosurgery, Department of Neurology, University of São Paulo Medical School, São Paulo, São Paulo, Brazil.
Campos ACP; Laboratory of Neuroscience, Hospital Sírio-Libanês, São Paulo, São Paulo, Brazil.
Cury RG; Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.
Martinez RCR; Hospital Israelita Albert Einstein, São Paulo, Brazil.
Pagano RL; Laboratory of Neuroscience, Hospital Sírio-Libanês, São Paulo, São Paulo, Brazil.
Fonoff ET; LIM/23, Institute of Psychiatry, University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.

NPJ Parkinsons Dis ; 10(1): 73, 2024 Mar 29.

Article em En | MEDLINE | ID: mdl-38553493

ABSTRACT

ABSTRACT

Pain control after deep brain stimulation (DBS) in Parkinson's disease (PD) remains unclear. Following six months, subthalamic (STN)-DBS reduced sensory complaints related to parkinsonism and bodily discomfort, increasing central beta-endorphin level. Pallidal GPi-DBS decreased bodily discomfort and beta-endorphin levels. Unexplained pain by other conditions and bodily discomfort were negatively correlated with beta-endorphin levels. Thus, DBS regulates central opioids, and prioritizing STN is important for PD patients with significant sensory complications.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: NPJ Parkinsons Dis Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

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