Severe cutaneous adverse reactions in a tertiary care center in Jamaica.
JAAD Int
; 15: 139-146, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38545494
ABSTRACT
Background:
Severe cutaneous adverse reactions (SCARs) are associated with morbidity and mortality.Objective:
The aim was to determine the different types of SCARs, their morphology, common offending drugs, interventions, and outcomes.Methods:
A retrospective cohort study was conducted of all patients admitted to the dermatology service at the University Hospital of the West Indies with Stevens-Johnson syndrome (SJS), SJS/toxic epidermal necrolysis overlap (TEN), TEN, drug reaction with eosinophilia and systemic symptoms and acute generalized exanthematous pustulosis between January 1, 2012 to June 1, 2022.Results:
Fifty-one cases (51) met the inclusion criteria for SCAR. SJS, SJS/TEN overlap and TEN together accounted for 71.2% of cases. SCARs were most frequent in the fourth, fifth and 6th decades of life and there was a female preponderance. Antibiotics (31%) and anticonvulsants (29%) were the most common causative agents for SCARs. Most patients had at least 1 complication. The liver was the most common extracutaneous organ affected. Mortality was 7.8%. The main cause of death was sepsis.Limitations:
Results were not generalizable. There were missing data and loss to follow-up.Conclusion:
Judicious use of antimicrobials and corticosteroids may be beneficial in treatment of severe cutaneous drug reactions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
JAAD Int
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Jamaica
País de publicação:
Estados Unidos