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Successful Desensitization to Sorafenib and Imatinib-A Report of Two Cases and a Literature Review.
Kusic, Natasa; Tomic Spiric, Vesna; Arandjelovic, Snezana; Peric Popadic, Aleksandra; Bozic Antic, Ivana; Dimitrijevic, Milan; Miskovic, Rada; Stefanovic, Ljiljana; Plavsic, Aleksandra.
Afiliação
  • Kusic N; Clinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, Serbia.
  • Tomic Spiric V; Clinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, Serbia.
  • Arandjelovic S; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Peric Popadic A; Clinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, Serbia.
  • Bozic Antic I; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Dimitrijevic M; Clinic of Allergy and Immunology, University Clinical Centre of Serbia, 11000 Beograd, Serbia.
  • Miskovic R; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Stefanovic L; Euromedik Healthcare System, 11158 Belgrade, Serbia.
  • Plavsic A; Faculty of Dentistry Pancevo, University Business Academy in Novi Sad, 21000 Novi Sad, Serbia.
Healthcare (Basel) ; 12(6)2024 Mar 07.
Article em En | MEDLINE | ID: mdl-38540565
ABSTRACT

BACKGROUND:

Drug desensitization allows for safe administration of a drug to a patient with a previous hypersensitivity reaction. Successful desensitization protocols have been described for different medications, including protocols for oncology patients. Few cases of desensitization to sorafenib and imatinib have been described in the literature so far.

OBJECTIVE:

The objective of this paper is to describe the process of the sorafenib and imatinib drug hypersensitivity diagnosis and desensitization process in two patients.

METHODS:

Two oncology patients who experienced non-immediate hypersensitivity reactions to sorafenib and imatinib underwent desensitization to these drugs. We designed a protocol for the first patient and used a modified protocol from the literature for the second patient.

RESULTS:

By using a slow desensitization technique and gradual tapering of corticosteroids and antihistamines, both patients reached the target dose of the incriminated drug.

CONCLUSIONS:

Desensitization to sorafenib and imatinib can be an effective therapeutic option in patients with hypersensitivity to those medications, without alternative treatment options.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Healthcare (Basel) Ano de publicação: 2024 Tipo de documento: Article País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Healthcare (Basel) Ano de publicação: 2024 Tipo de documento: Article País de publicação: Suíça