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Effectiveness of metformin to pregnant women with PCOS to reduce spontaneous abortion and gestational diabetes mellitus: a protocol for an overview of reviews.
Nassif, Darmaris Souza; Januário, Bianca Lúcia; Sousa, Bianca Antunes; Thabane, Lehana; Abbade, Joelcio Francisco.
Afiliação
  • Nassif DS; Botucau Medical School - Department of Obstetrics and Gynecology, São Paulo State University - UNESP, Botucatu, São Paulo, Brazil.
  • Januário BL; Botucau Medical School, UNESP, Sao Paulo, Brazil.
  • Sousa BA; Botucau Medical School, UNESP, Sao Paulo, Brazil.
  • Thabane L; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
  • Abbade JF; Biostatistics Unit, St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
BMJ Open ; 14(3): e078217, 2024 Mar 25.
Article em En | MEDLINE | ID: mdl-38531582
ABSTRACT

INTRODUCTION:

Polycystic ovary syndrome (PCOS) is a globally prevalent endocrinological disorder and has been associated with poor pregnancy outcomes, including a higher rate of gestational diabetes and miscarriage. Metformin is among the drugs investigated to improve the prognosis of pregnant women with PCOS.

OBJECTIVE:

To conduct an overview of systematic reviews examining the effects of metformin versus placebo or no intervention throughout pregnancy among pregnant women with a preconception PCOS diagnosis to reduce the incidence of miscarriage and gestational diabetes. METHODS AND

ANALYSIS:

We will perform an overview of systematic reviews by searching Embase, PubMed, Virtual Health Library, Cochrane Central Register of Controlled Trials, Trip Database, Scopus, Web of Science and Cumulative Index to Nursing and Allied Health Literature from inception to 17 August 2023. Language, publication status and year indexed or published filters will not be applied. Two reviewers will independently screen and select papers, assess their quality, evaluate their risk of bias and collect the data. The included reviews will be summarised narratively. The quality and risk of bias of the systematic review and meta-analysis studies included will be assessed using AMSTAR 2 (A Measurement Tool to Assess Systematic Reviews, Second Version) and ROBIS (Risk of Bias in Systematic Reviews), respectively. ETHICS AND DISSEMINATION This overview of reviews will analyse data from systematic reviews on the use of metformin for prepregnancy diagnosis of PCOS to reduce adverse outcomes. As there will be no primary data collection, a formal ethical analysis is unnecessary. The study outcomes will be submitted to a peer-reviewed journal and presented at conferences. PROSPERO REGISTRATION NUMBER CRD42023441488.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Aborto Espontâneo / Diabetes Gestacional / Revisões Sistemáticas como Assunto / Hipoglicemiantes / Metformina Limite: Female / Humans / Pregnancy Idioma: En Revista: BMJ Open Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Aborto Espontâneo / Diabetes Gestacional / Revisões Sistemáticas como Assunto / Hipoglicemiantes / Metformina Limite: Female / Humans / Pregnancy Idioma: En Revista: BMJ Open Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido