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Single nucleotide polymorphisms of ANKK1, DDR4, and GRIN2B genes predict behavior in a prospective cohort of Mexican children and adolescents.
Moctezuma, Barbara; Santiago, Ángel; Burguete-García, Ana; Martínez-Barnetche, Jesus; Morales-Gómez, Claudia; Hernandez-Chavez, Carmen; Gil, Gabriela; Peterson, Karen E; Tellez-Rojo, Martha M; Lamadrid-Figueroa, Hector.
Afiliação
  • Moctezuma B; School of Public Health of Mexico, National Institute of Public Health, Cuernavaca, Mexico.
  • Santiago Á; Department of Perinatal Health, National Institute of Public Health, Cuernavaca, Mexico.
  • Burguete-García A; Center for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico.
  • Martínez-Barnetche J; Center for Infectious Disease Research, National Institute of Public Health, Cuernavaca, Mexico.
  • Morales-Gómez C; Epidemiologic Surveillance, Mexican Institute of Social Security-Bienestar, Mexico City, Mexico.
  • Hernandez-Chavez C; Department of Developmental Neurobiology, National Institute of Perinatology, Mexico City, Mexico.
  • Gil G; Department of Developmental Neurobiology, National Institute of Perinatology, Mexico City, Mexico.
  • Peterson KE; Nutritional Sciences Department, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
  • Tellez-Rojo MM; Center for Research in Nutrition and Health, National Institute of Public Health, Cuernavaca, Mexico.
  • Lamadrid-Figueroa H; Department of Perinatal Health, National Institute of Public Health, Cuernavaca, Mexico.
Int J Dev Neurosci ; 2024 Mar 26.
Article em En | MEDLINE | ID: mdl-38530142
ABSTRACT
Numerous studies have established associations between single nucleotide polymorphisms (SNPs) and various behavioral and neurodevelopmental conditions. This study explores the links between SNPs in candidate genes involved in central nervous system (CNS) physiology and their implications for the behavioral and emotional aspects in children and teenagers. A total of 590 participants, aged 7-15 years, from the Early Life Exposures In Mexico To Environmental Toxicants (ELEMENT) cohort study in Mexico City, underwent genotyping for at least one of 15 CNS gene-related SNPs at different timepoints. We employed multiple linear regression models to assess the potential impact of genetic variations on behavioral and cognitive traits, as measured by the Behavioral Assessment System for Children (BASC) and Conners parent rating scales. Significant associations were observed, including the rs1800497 TC genotype (ANKK1) with the Cognitive Problems/Inattention variable (p value = 0.003), the rs1800955 CT genotype (DDR4) with the Emotional Lability Global index variable (p value = 0.01), and the rs10492138 GA and rs7970177 TC genotypes (GRIN2B) with the Depression variable (p values 0.007 and 0.012, respectively). These finds suggest potential genetic profiles associated with "risk" and "protective" behaviors for these SNPs. Our results provide valuable insights into the role of genetic variations in neurobehavior and highlight the need for further research in the early identification and intervention in individuals at risk for these conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: Int J Dev Neurosci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: Int J Dev Neurosci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos