Anaplastic large cell lymphoma with ALK::ATIC fusion mimicking a histiocytic sarcoma debuting as an anterior thoracic soft tissue tumor with exceptional clinicopathological, morphological and molecular features.
Thorac Cancer
; 15(13): 1103-1105, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38523398
ABSTRACT
A 56-year-old woman debuted with a palpable painless mass in the anterior thorax wall at the level of the second and third right parasternal intercostal space, which progressively increased in size over 5 months accompanied by localized skin rash, mild dyspnea and chest pain when changing position. Imaging studies showed a soft tissue mass measuring 75 × 62 mm and a density of 34 Hounsfield Units that had caused the lysis of the costal arches and grew expansively towards the anterior mediastinum, without identifying mediastinal adenopathies only by this imaging method. Core biopsy was performed, which was initially diagnosed as histiocytic sarcoma (HS); however, when the diagnostic panel was expanded to include molecular and NGS studies, the final diagnosis was anaplastic large cell lymphoma with ALKATIC fusion. Here, we report a very rare neoplasm with unusual clinical presentation, histopathology and molecular features.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfoma Anaplásico de Células Grandes
/
Sarcoma Histiocítico
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Thorac Cancer
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Singapura