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Investigation of the Relationship of Nesfatin-1, Adropin Levels and Claudin-2, Renalase Immunoreactivity with Kidney Function in an Experimental Hypertension Model.
Aydin, Muhammed Ali; Aydogdu, Nurettin; Tastekin, Ebru; Firat, Nihayet; Yalcinkaya Yavuz, Ozlem.
Afiliação
  • Aydin MA; Trakya University Faculty of Medicine, Department of Physiology, Edirne 22030, Turkiye.
  • Aydogdu N; Inonu University Faculty of Medicine, Department of Physiology, Malatya 44280, Turkiye.
  • Tastekin E; Trakya University Faculty of Medicine, Department of Pathology, Edirne 22030, Turkiye.
  • Firat N; Trakya University Faculty of Medicine, Department of Physiology, Edirne 22030, Turkiye.
  • Yalcinkaya Yavuz O; Trakya University Faculty of Medicine, Department of Physiology, Edirne 22030, Turkiye.
P R Health Sci J ; 43(1): 39-45, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38512760
ABSTRACT

OBJECTIVE:

Hypertension is one of the cardiovascular diseases that causes the most mortality, and 95% of the causes are unknown. The aim of the study was to examine the possible correlation of nesfatin-1 levels, adropin levels, claudin-2 immunoreactivity (claudin-2 expression in the renal proximal tubule), and renalase immunoreactivity (renalase expression in the renal proximal tubule) with arterial blood pressure, kidney function, and kidney damage.

METHODS:

Adult male Sprague Dawley rats were divided into control and hypertension groups (8 per group). Angiotensin II vehicle was given to the control group and angiotensin II (0.7 mg/kg/day) to the hypertension group, both via an osmotic mini pump for 7 days. The animals blood pressures were measured by tail cuff plethysmography on days 1, 3, 5, and 7. On day 7, 24-hour urine, blood, and tissues were collected from the rats.

RESULTS:

In the hypertension group compared with the control group, there was an increase in systolic blood pressure levels after day 1. While claudin-2 immunoreactivity was reduced in the kidneys, renalase immunoreactivity was increased. There was a decrease in creatinine clearance and an increase in fractional potassium excretion (P < .05).

CONCLUSION:

Our results showed that claudin-2 and renalase are associated with renal glomerular and tubular dysfunction and may play discrete roles in the pathogenesis of hypertension. We believe that these potential roles warrant further investigation.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Proteínas Sanguíneas / Claudina-2 / Hipertensão / Glomérulos Renais / Túbulos Renais / Monoaminoxidase Limite: Animals Idioma: En Revista: P R Health Sci J Ano de publicação: 2024 Tipo de documento: Article País de publicação: Porto Rico
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Proteínas Sanguíneas / Claudina-2 / Hipertensão / Glomérulos Renais / Túbulos Renais / Monoaminoxidase Limite: Animals Idioma: En Revista: P R Health Sci J Ano de publicação: 2024 Tipo de documento: Article País de publicação: Porto Rico