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Temporal evolution of postsurgical bone repair in a rabbit model: A [99mTc]Tc-MDP scintigraphic study.
Yoneda, A; Lacerda, K J C C de; Alexandre-Santos, L; Itikawa, E N; Louzada-Junior, P; Wichert-Ana, L.
Afiliação
  • Yoneda A; Laboratório de Medicina Nuclear e PET/CT, Departamento de Imagem Médica, Hematologia e Oncologia Clínica, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
  • Lacerda KJCC; Laboratório de Medicina Nuclear e PET/CT, Departamento de Imagem Médica, Hematologia e Oncologia Clínica, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
  • Alexandre-Santos L; Laboratório de Medicina Nuclear e PET/CT, Departamento de Imagem Médica, Hematologia e Oncologia Clínica, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
  • Itikawa EN; Instituto de Física, Universidade Federal de Goiás, Goiânia, GO, Brasil.
  • Louzada-Junior P; Divisão de Reumatologia, Departamento de Medicina Interna, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
  • Wichert-Ana L; Laboratório de Medicina Nuclear e PET/CT, Departamento de Imagem Médica, Hematologia e Oncologia Clínica, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Braz J Med Biol Res ; 57: e12953, 2024.
Article em En | MEDLINE | ID: mdl-38511767
ABSTRACT
Bone regeneration is crucial for repairing bone tissue following various injuries. Research techniques that enable the study of metabolic changes in bone tissue under different conditions are important for understanding bone repair and remodeling. This study used bone scintigraphy to evaluate osteogenesis secondary to osteotomy in a preclinical model of New Zealand rabbits. For this purpose, we conducted a longitudinal, prospective, case-control study in which scintigraphic variables were measured in both the right forearm (case-operated) and the left forearm (control - non-operated). The study sample consisted of 10 rabbits subjected to osteotomy, followed by a 12-week postoperative evaluation period, divided into six imaging stages at 1, 2, 3, 4, 8, and 12 weeks. We observed that the operated forearm showed significantly higher external radiation than the control side, using the pinhole collimator, denoting an increase in the biodistribution and tropism of the radiopharmaceutical to the operated forearm. Among the three evaluated time points, osteoblastic activity was highest in the second week and presented a significant decline in the 8th and 12th weeks, denoting regeneration and resolution of the surgical injury; the control forearm was also influenced by the inactivity imposed by the operated forearm. This fact was notably evidenced by the reduction in the metabolic activity of osteoblasts in the left forearm. Our study suggested that bone scintigraphy was sensitive enough to semi-quantitatively differentiate the metabolic activity of osteoblasts in the operated forearm in the three temporal landmarks evaluated in the study.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Radiofarmacêuticos Limite: Animals Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Radiofarmacêuticos Limite: Animals Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil