Papillary renal cell carcinoma with extensive spindle cell foci: mimicker of mucinous tubular and spindle cell carcinoma.

Rajack, Fareed; Medford, Shawn; Naab, Tammey

Rajack, Fareed; Medford, Shawn; Naab, Tammey.

Afiliação

Rajack F; Howard University Hospital, Department of Pathology and Laboratory Medicine, Washington, D.C., United States of America.
Medford S; Howard University College of Medicine, Washington, D.C., United States of America.
Naab T; Howard University Hospital, Department of Pathology and Laboratory Medicine, Washington, D.C., United States of America.

Autops Case Rep ; 14: e2024479, 2024.

Article em En | MEDLINE | ID: mdl-38487036

ABSTRACT

ABSTRACT

Papillary renal cell carcinoma (PRCC) is the second most common renal cell carcinoma (RCC), accounting for 10-15% of cases. Mucinous tubular and spindle cell carcinoma (MTSCC), on the other hand, accounts for only 1% of renal tumors and has a more favorable prognosis compared to PRCC. We report a 75-year-old female with a left upper pole solid renal mass displaying features of both papillary renal cell carcinoma (PRCC) and mucinous tubular and spindle cell carcinoma (MTSC). In this case, a shaggy luminal surface, multiple papillations, and psammoma bodies, absence of E-cadherin expression, and strong CD10 expression favored PRCC. Both immunohistochemistry and genomic analysis are critical to diagnose and differentiate tumors that may have overlapping features accurately.

Palavras-chave

Carcinoma, Papillary; Hippo Signaling Pathway; Immunohistochemistry; Kidney Neoplasms; Nephrectomy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Autops Case Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil

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