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EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features.
Noronha, Mariana Saturnino de; Viana, Karolina Skarlet Silva; Aguiar, Maria Cássia Ferreira de; Squarize, Cristiane Helena; Abreu, Mauro Henrique Nogueira Guimarães de; Mendonça, Elismauro Francisco; Bernardes, Vanessa de Fátima.
Afiliação
  • Noronha MS; Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil.
  • Viana KSS; Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil.
  • Aguiar MCF; Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil.
  • Squarize CH; University of Michigan, School of Dentistry, Department of Periodontics and Oral Medicine, Ann Arbor, MI, USA.
  • Abreu MHNG; Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Community and Preventive Dentistry, Belo Horizonte, MG, Brazil.
  • Mendonça EF; Universidade Federal de Goiás - UFG, School of Dentistry, Department of Stomatologic Sciences, Goiânia, GO, Brazil.
  • Bernardes VF; Universidade Federal de Minas Gerais - UFMG, Biological Sciences Institute, Department of Pathology, Belo Horizonte, MG, Brazil.
Braz Oral Res ; 38: e018, 2024.
Article em En | MEDLINE | ID: mdl-38477804
ABSTRACT
The aim of this study was to evaluate the expression of the EZH2 protein and describe the clinical and microscopic characteristics of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA). The study included 16 ACC cases and 12 PA. All ACC and PA cases were positive for EZH2 and the ACC samples showed significantly higher EZH2 expression. The clinical and microscopic covariates were described in relation to EZH2 staining in ACC samples. The highest mean values of EZH2 were observed in cases with local metastasis, recurrence, perineural invasion, and predominantly cribriform growth pattern without solid areas. EZH2 is a potential marker of malignancy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Adenoide Cístico / Adenoma Pleomorfo Limite: Humans Idioma: En Revista: Braz Oral Res Assunto da revista: ODONTOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Adenoide Cístico / Adenoma Pleomorfo Limite: Humans Idioma: En Revista: Braz Oral Res Assunto da revista: ODONTOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil