Your browser doesn't support javascript.
loading
New immunological aspects of peri-implantitis.
Bertoldo, Bárbara Bellocchio; Paulo, Guilherme Oliveira; Furtado, Taíssa Cássia de Souza; Pereira, Thiago Lima; Rodrigues Junior, Virmondes; Rodrigues, Denise Bertulucci Rocha; de Faria, Juliana Barbosa; Rosa, Rodrigo César; Pereira, Sanívia Aparecida de Lima.
Afiliação
  • Bertoldo BB; Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
  • Paulo GO; Centro Universitário Funorte, Uberaba, MG, Brazil.
  • Furtado TCS; Universidade de Uberaba, Uberaba, MG, Brazil.
  • Pereira TL; Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
  • Rodrigues Junior V; Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
  • Rodrigues DBR; Universidade de Uberaba, Uberaba, MG, Brazil.
  • de Faria JB; Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
  • Rosa RC; Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
  • Pereira SAL; Universidade de Uberaba, Uberaba, MG, Brazil.
Einstein (Sao Paulo) ; 22: eAO0396, 2024.
Article em En | MEDLINE | ID: mdl-38477721
ABSTRACT

BACKGROUND:

The authors compared the levels of HIF1-α, VEGF, TNF-α, and IL-10 in peri-implant crevicular fluid between patients with or without peri-implantitis. HIF-1α levels were significantly high in the peri-implantitis possibly due to hypoxia triggered by persistent inflammation.

OBJECTIVE:

This study aimed to compare the levels of HIF1-α, VEGF, TNF-α, and IL-10 in the peri-implant crevicular fluid of patients with and without peri-implantitis.

METHODS:

Forty patients, comprising 16 with and 24 without peri-implantitis were selected.

RESULTS:

Patients with peri-implantitis exhibited significantly higher HIF-1α levels than those without peri-implantitis (p=0.0005). TNF-α revealed significant positive correlations with IL-10 (p=0.0008) and VEGF (p=0.0246), whereas HIF-1α and IL-10 levels (p=0.0041) demonstrated a negative and significative correlation in the peri-implantitis group.

CONCLUSION:

This study, for the first time demonstrates the balance of HIF-1α, TNFα, IL-10, and VEGF in peri-implantitis. It shows an elevated HIF-1α levels in patients with peri-implantitis, which could have stemmed from persistent inflammation- triggered hypoxia. Furthermore, the positive correlation between TNF-α and VEGF suggests intensified proinflammatory activity in peri-implantitis. Nevertheless, further studies are essential to understand these immune dynamics in peri-implantitis.

BACKGROUND:

Higher levels of HIF-1α in patients with peri-implantitis occurred possibly due to persistent hypoxia triggered by inflammation.

BACKGROUND:

Tissue hypoxia in peri-implantitis induced increase in HIF-1α consequently increased VEGF and angiogenesis, contributing to the persistence of inflammation.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peri-Implantite Limite: Humans Idioma: En Revista: Einstein (Sao Paulo) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peri-Implantite Limite: Humans Idioma: En Revista: Einstein (Sao Paulo) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil