Elderly-onset rheumatoid arthritis receives less aggressive therapies than young-onset rheumatoid arthritis in an Argentinian cohort.
Reumatol Clin (Engl Ed)
; 20(3): 136-141, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38443231
ABSTRACT
OBJECTIVES:
When rheumatoid arthritis (RA) starts after the age of 60 it is called elderly-onset rheumatoid arthritis (EORA) and when it starts earlier, young-onset rheumatoid arthritis. (YORA). There are few Latin American studies that compared both groups. The objective of the study was to evaluate differences in the clinical characteristics, evolution and treatment among patients with RA with onset before or after 60 years of age. MATERIALS ANDMETHODS:
Observational study of patients with RA attended consecutively in four centers in Argentina. Sociodemographic data, comorbidities, clinical manifestations at diagnosis, presence of rheumatoid factor and/or anti-CCP (cyclic citrullinated peptide) and treatments received were collected. At the last visit, swollen and tender joints, assessment of disease activity by the patient and physician, the presence of radiographic erosions, and functional status using the HAQ-DI were recorded.RESULTS:
51 patients from each group were analyzed. The EORA group had a significantly higher proportion of smokers (58.8% vs. 35.3%, pâ¯=â¯0.029), cardiovascular history (54.9% vs. 21.6%, pâ¯=â¯0.001), abrupt onset (49% vs. 29.4%, pâ¯=â¯0.034) or with symptoms similar to PMR (19.6% vs. 0%, pâ¯=â¯0.001). Lower methotrexate doses were used in the EORA group 19â¯mg (15-25) vs. 21.9â¯mg (20-25) (pâ¯=â¯0.0036) and more frequently did not receive bDMARDs or tsDMARDs. DISCUSSION ANDCONCLUSIONS:
The benefits of intensive treatment in patients with RA have been described. In this study, the use of DMARDs in the EORA group was less intensive, suggesting that advanced age constitutes a barrier in the therapeutic choice.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Antirreumáticos
Limite:
Aged
/
Humans
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Reumatol Clin (Engl Ed)
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Espanha