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Analysis of Complications in Multilevel Anterior Cervical Discectomy and Fusion Using Osteobiologics Other than Bone Morphogenetic Protein: A Systematic Review.
Cabrera, Juan P; Agarwal, Neha; Mesregah, Mohamed Kamal; Rodrigues-Pinto, Ricardo; Wu, Yabin; Martin, Christopher; Buser, Zorica; Wang, Jeffrey C; Meisel, Hans Jörg.
Afiliação
  • Cabrera JP; Department of Neurosurgery, Hospital Clínico Regional de Concepción, Concepción, Chile.
  • Agarwal N; Faculty of Medicine, University of Concepción, Concepción, Chile.
  • Mesregah MK; Department of Neurosurgery, BG Klinikum Bergmannstrost Halle, Halle, Germany.
  • Rodrigues-Pinto R; Department of Orthopaedic Surgery, Menoufia University Faculty of Medicine, Shebin El-Kom, Menoufia, Egypt.
  • Wu Y; Spinal Unit (UVM). Department of Orthopaedics, Centro Hospitalar Universitário de Santo António; ICBAS - School of Medical and Biomedical Sciences; Hospital CUF Trindade, Porto, Portugal.
  • Martin C; Research Department, AO Spine, AO Foundation, Davos, Switzerland.
  • Buser Z; Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN, USA.
  • Wang JC; Gerling Institute, Brooklyn, NY, USA.
  • Meisel HJ; Department of Orthopedic Surgery, NYU Grossman School of Medicine, New York, NY, USA.
Global Spine J ; 14(2_suppl): 86S-93S, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38421321
ABSTRACT
STUDY

DESIGN:

Systematic review.

OBJECTIVES:

The aim of this study is to analyze the complications related to multilevel anterior cervical discectomy and fusion (ACDF) using osteobiologics other than bone morphogenetic protein (BMP).

METHODS:

A systematic review of the literature was conducted using PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov databases. The search to identify studies reporting complications in multilevel ACDF surgery using osteobiologics other than bone morphogenetic protein was performed in August 2020. The study was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA).

RESULTS:

A total of 584 articles were found after searching the databases and removing duplicates. Next, screening was performed in a double reviewer process, and 153 eligible articles-with 4 retrospective studies-in full-text were selected; these met all inclusion criteria. A total of 197 patients received 3-level ACDF, while 72 patients received 4-level ACDF. Osteobiologics were used in all selected articles, allograft was used in 4 studies, autologous bone graft was utilized in 3 articles, and hydroxyapatite was used in 1 article. The main complications reported were dysphagia, adjacent segment disease, and pseudarthrosis.

CONCLUSIONS:

Given the limited evidence, no conclusions on complications in multilevel ACDF using osteobiologics other than BMP could be made. However, descriptively, the most common complications found were dysphagia, adjacent segment disease, and pseudoarthrosis. Further prospective studies separately analyzing complications in multilevel ACDF by osteobiologics and a number of treated levels are needed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Global Spine J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Global Spine J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido