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A systematic review and meta-analysis of serum lipid concentrations in people with Down syndrome.
Gastelum Guerrero, Carolina; Cháidez Fernández, Yuridia Lizet; Magaña Ordorica, Dalia; Berger, Heidi; Vazquez Landrove, Marilyn; Guadrón Llanos, Alma; Angulo Rojo, Carla; Magaña Gómez, Javier.
Afiliação
  • Gastelum Guerrero C; Facultad de Ciencias de la Nutrición y Gastronomía, Universidad Autónoma de Sinaloa, Culiacán, Mexico.
  • Cháidez Fernández YL; Facultad de Ciencias de la Nutrición y Gastronomía, Universidad Autónoma de Sinaloa, Culiacán, Mexico.
  • Magaña Ordorica D; Facultad de Ciencias de la Nutrición y Gastronomía, Universidad Autónoma de Sinaloa, Culiacán, Mexico.
  • Berger H; Department of Mathematics, Simpson College, Indianola, Iowa, USA.
  • Vazquez Landrove M; Department of Mathematics, Simpson College, Indianola, Iowa, USA.
  • Guadrón Llanos A; Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Mexico.
  • Angulo Rojo C; Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Mexico.
  • Magaña Gómez J; Facultad de Ciencias de la Nutrición y Gastronomía, Universidad Autónoma de Sinaloa, Culiacán, Mexico.
J Intellect Disabil Res ; 68(6): 553-563, 2024 06.
Article em En | MEDLINE | ID: mdl-38404114
ABSTRACT

BACKGROUND:

Down syndrome (DS) is the most prevalent chromosomal disorder, being the leading cause of intellectual disability. The increased life expectancy of individuals with DS has led to a shift in the incidence of non-communicable chronic diseases, resulting in new concerns, particularly cardiovascular disease (CVD) and Alzheimer's disease. This study aimed to analyse the blood lipid profile of a large DS cohort to establish a baseline for evaluating health risk parameters.

METHODS:

A comprehensive literature search was conducted on PubMed and Virtual Health Library databases to identify original articles published before July 2022. Selected studies were included in the meta-analysis.

RESULTS:

Fifteen studies reporting serum lipid levels in individuals with DS were incorporated into the analysis. The meta-analysis used the means and standard deviations extracted from the selected studies. The analysis encompassed 671 participants in the DS group and 898 euploid controls. The results indicated significant differences in total cholesterol [C] (mean difference [MD] -3.34; CI 95% -4.94 to -1.73; P < 0.0001), HDL-C (MD -3.39; CI 95% -6.72 to -0.06; P = 0.05) and triglycerides (MD 21.48; CI 95% 9.32 to 33.65; P = 0.0005) levels between individuals with DS and their control counterparts.

CONCLUSIONS:

Individuals with DS have less favourable blood lipid concentrations than their controls, particularly HDL-C, triglycerides, and total-C, even when grouped by age. These findings underscore the importance of closer monitoring of lipid profiles in people with DS and the necessity for specific cut-offs for this population, considering the risk for ischemic heart and Alzheimer's diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Down Limite: Adolescent / Adult / Humans Idioma: En Revista: J Intellect Disabil Res Assunto da revista: TRANSTORNOS MENTAIS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Down Limite: Adolescent / Adult / Humans Idioma: En Revista: J Intellect Disabil Res Assunto da revista: TRANSTORNOS MENTAIS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido