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In Silico Analysis of Genes Associated with the Pathogenesis of Odontogenic Keratocyst.
Ramírez-Martínez, Carla Monserrat; Legorreta-Villegas, Itzel; Mejía-Velázquez, Claudia Patricia; Portilla-Robertson, Javier; Gaitán-Cepeda, Luis Alberto; Paramo-Sánchez, Jessica Tamara; Chanes-Cuevas, Osmar Alejandro; Alonso-Moctezuma, Alejandro; Jacinto-Alemán, Luis Fernando.
Afiliação
  • Ramírez-Martínez CM; Oral Medicine and Pathology Department, Postgraduate and Research Division, Dentistry School, National Autonomous University of Mexico, Mexico City 04510, Mexico.
  • Legorreta-Villegas I; Oral Medicine and Pathology Department, Postgraduate and Research Division, Dentistry School, National Autonomous University of Mexico, Mexico City 04510, Mexico.
  • Mejía-Velázquez CP; Oral Medicine and Pathology Department, Postgraduate and Research Division, Dentistry School, National Autonomous University of Mexico, Mexico City 04510, Mexico.
  • Portilla-Robertson J; Oral Medicine and Pathology Department, Postgraduate and Research Division, Dentistry School, National Autonomous University of Mexico, Mexico City 04510, Mexico.
  • Gaitán-Cepeda LA; Oral Medicine and Pathology Department, Postgraduate and Research Division, Dentistry School, National Autonomous University of Mexico, Mexico City 04510, Mexico.
  • Paramo-Sánchez JT; Oral Medicine and Pathology Department, Postgraduate and Research Division, Dentistry School, National Autonomous University of Mexico, Mexico City 04510, Mexico.
  • Chanes-Cuevas OA; Dental Biomaterials Laboratory, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, Mexico.
  • Alonso-Moctezuma A; Oral and Maxillofacial Surgery Department, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, Mexico.
  • Jacinto-Alemán LF; Oral Medicine and Pathology Department, Postgraduate and Research Division, Dentistry School, National Autonomous University of Mexico, Mexico City 04510, Mexico.
Int J Mol Sci ; 25(4)2024 Feb 17.
Article em En | MEDLINE | ID: mdl-38397053
ABSTRACT
Odontogenic keratocyst (OK) is a benign intraosseous cystic lesion characterized by a parakeratinized stratified squamous epithelial lining with palisade basal cells. It represents 10-12% of odontogenic cysts. The changes in its classification as a tumor or cyst have increased interest in its pathogenesis.

OBJECTIVE:

Identify key genes in the pathogenesis of sporadic OK through in silico analysis. MATERIALS AND

METHODS:

The GSE38494 technical sheet on OK was analyzed using GEOR2. Their functional and canonical signaling pathways were enriched in the NIH-DAVID bioinformatic platform. The protein-protein interaction network was constructed by STRING and analyzed with Cytoscape-MCODE software v 3.8.2 (score > 4). Post-enrichment analysis was performed by Cytoscape-ClueGO.

RESULTS:

A total of 768 differentially expressed genes (DEG) with a fold change (FC) greater than 2 and 469 DEG with an FC less than 2 were identified. In the post-enrichment analysis of upregulated genes, significance was observed in criteria related to the organization of the extracellular matrix, collagen fibers, and endodermal differentiation, while the downregulated genes were related to defensive response mechanisms against viruses and interferon-gamma activation.

CONCLUSIONS:

Our in silico analysis showed a significant relationship with mechanisms of extracellular matrix organization, interferon-gamma activation, and response to viral infections, which must be validated through molecular assays.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cistos Odontogênicos / Tumores Odontogênicos Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cistos Odontogênicos / Tumores Odontogênicos Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça