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Dynamic Role of miRNAs in Salivary Gland Carcinomas: From Biomarkers to Therapeutic Targets.
Kimura, Talita de Carvalho; de Lima-Souza, Reydson Alcides; Maciel, Tayná Figueiredo; Kowalski, Luiz Paulo; Coutinho-Camillo, Cláudia Malheiros; Egal, Erika Said Abu; Altemani, Albina; Mariano, Fernanda Viviane.
Afiliação
  • Kimura TC; Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil.
  • de Lima-Souza RA; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
  • Maciel TF; Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil.
  • Kowalski LP; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
  • Coutinho-Camillo CM; Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil.
  • Egal ESA; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
  • Altemani A; Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Mariano FV; International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
Head Neck Pathol ; 18(1): 12, 2024 Feb 23.
Article em En | MEDLINE | ID: mdl-38393615
ABSTRACT

BACKGROUND:

Salivary gland carcinomas (SGCs) are a rare group of malignant neoplasms of the head and neck region. MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been associated with the control biological process and oncogenic mechanism by the regulation of gene expression at the post-transcriptional level. Recent evidence has suggested that miRNA expression may play a role in the tumorigenesis and carcinogenesis process in SGCs.

METHODS:

This review provides a comprehensive literature review of the role of miRNAs expression in SGCs focusing on the diagnostic, prognostic, and therapeutic applications.

RESULTS:

In this review, numerous dysregulated miRNAs have demonstrated an oncogenic and suppressor role in SGCs.

CONCLUSION:

In the future, these miRNAs may eventually constitute useful diagnostic and prognostic biomarkers that may lead to a better understanding of SGCs oncogenesis. Additionally, the development of therapeutic agents based on miRNAs may be a promising target in SGC treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Carcinoma / MicroRNAs Limite: Humans Idioma: En Revista: Head Neck Pathol Assunto da revista: NEOPLASIAS / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Carcinoma / MicroRNAs Limite: Humans Idioma: En Revista: Head Neck Pathol Assunto da revista: NEOPLASIAS / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos