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Effects of PM10 Airborne Particles from Different Regions of a Megacity on In Vitro Secretion of Cytokines by a Monocyte Line during Different Seasons.
Meraz-Cruz, Noemi; Manzano-León, Natalia; Sandoval-Colin, Daniel Eduardo; García de León Méndez, María Del Carmen; Quintana-Belmares, Raúl; Tapia, Laura Sevilla; Osornio-Vargas, Alvaro R; Buxton, Miatta A; O'Neill, Marie S; Vadillo-Ortega, Felipe.
Afiliação
  • Meraz-Cruz N; Unidad de Vinculación Científica de la Facultad de Medicina, UNAM en el Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.
  • Manzano-León N; Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Mexico City 14080, Mexico.
  • Sandoval-Colin DE; Unidad de Vinculación Científica de la Facultad de Medicina, UNAM en el Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.
  • García de León Méndez MDC; Unidad de Vinculación Científica de la Facultad de Medicina, UNAM en el Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.
  • Quintana-Belmares R; Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Mexico City 14080, Mexico.
  • Tapia LS; Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Mexico City 14080, Mexico.
  • Osornio-Vargas AR; Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 1C9, Canada.
  • Buxton MA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • O'Neill MS; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • Vadillo-Ortega F; Department of Environmental Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Toxics ; 12(2)2024 Feb 15.
Article em En | MEDLINE | ID: mdl-38393244
ABSTRACT
Several epidemiological studies have demonstrated that particulate matter (PM) in air pollution can be involved in the genesis or aggravation of different cardiovascular, respiratory, perinatal, and cancer diseases. This study assessed the in vitro effects of PM10 on the secretion of cytokines by a human monocytic cell line (THP-1). We compared the chemotactic, pro-inflammatory, and anti-inflammatory cytokines induced by PM10 collected for two years during three different seasons in five different Mexico City locations. MIP-1α, IP-10, MCP-1, TNF-α, and VEGF were the main secretion products after stimulation with 80 µg/mL of PM10 for 24 h. The THP-1 cells showed a differential response to PM10 obtained in the different sites of Mexico City. The PM10 from the north and the central city areas induced a higher pro-inflammatory cytokine response than those from the south. Seasonal pro-inflammatory cytokine secretion always exceeded anti-inflammatory secretion. The rainy-season-derived particles caused the lowest pro-inflammatory effects. We concluded that toxicological assessment of airborne particles provides evidence supporting their potential role in the chronic exacerbation of local or systemic inflammatory responses that may worsen the evolution of some chronic diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Toxics Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Toxics Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça