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Molecular epidemiology of Candida africana isolates collected from vagina swabs in French Guiana.
Bigot, Jeanne; Kalboussi, Yasmine; Bonkoto Nkoy, Yannick; Benmostefa, Alexis; Vellaissamy, Sandra; Benzerara, Laurent; Sainte-Rose, Vincent; Blanchet, Denis; Demar, Magalie; Guitard, Juliette; Hennequin, Christophe.
Afiliação
  • Bigot J; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, F-75012 Paris, France.
  • Kalboussi Y; Service de Parasitologie-Mycologie, Hôpital Saint-Antoine, 75012 Paris, France.
  • Bonkoto Nkoy Y; Service de Parasitologie-Mycologie, Hôpital Saint-Antoine, 75012 Paris, France.
  • Benmostefa A; Service de Parasitologie-Mycologie, Hôpital Saint-Antoine, 75012 Paris, France.
  • Vellaissamy S; GHU Paris Psychiatrie et Neuroscience, Microbiology Department, F-75014 Paris, France.
  • Benzerara L; Service de Parasitologie-Mycologie, Hôpital Saint-Antoine, 75012 Paris, France.
  • Sainte-Rose V; Service de Parasitologie-Mycologie, Hôpital Saint-Antoine, 75012 Paris, France.
  • Blanchet D; DFR Santé, Université de Guyane, Laboratoire, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana.
  • Demar M; DFR Santé, Université de Guyane, Laboratoire, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana.
  • Guitard J; DFR Santé, Université de Guyane, Laboratoire, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana.
  • Hennequin C; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, F-75012 Paris, France.
Med Mycol ; 62(3)2024 Mar 07.
Article em En | MEDLINE | ID: mdl-38389256
ABSTRACT
Previous molecular studies have shown that Candida africana corresponds to the clade 13 of Candia albicans. It has been mostly involved in vulvovaginal candidiasis worldwide but few data exist in South America. The aim of our study was to investigate the prevalence of C. africana in women living in French Guiana. For this, we first set up a fluorescent-intercalating-dye-real time Polymerase Chain Reaction (PCR) targeting the hyphal wall protein 1 gene. The test was applied to 212 C. albicans isolates collected from May to August 2019 from vaginal swabs, allowing the identification of six women harboring C. africana (eight isolates). The in vitro susceptibility of these eight isolates to six antifungal drugs was also evaluated. No demographics or clinical-specific features could be demonstrated. Genetic diversity of those isolates was analyzed through multilocus sequence typing and showed that diploid sequence type 182 was predominant (n = 6) and allowed the report of a new diploid sequence type.
Candida africana, the clade 13 of C. albicans, is characterized by specific genetic and phenotypic traits. Using a new molecular technique, we report a high prevalence of C. africana in vaginal swabs from patients living in French Guiana. The worldwide predominant genotype was detected in all but one patient.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida / Candidíase Vulvovaginal Limite: Female / Humans País/Região como assunto: America do sul / Caribe ingles / Guyana / Guyana francesa Idioma: En Revista: Med Mycol Assunto da revista: MEDICINA VETERINARIA / MICROBIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: França País de publicação: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida / Candidíase Vulvovaginal Limite: Female / Humans País/Região como assunto: America do sul / Caribe ingles / Guyana / Guyana francesa Idioma: En Revista: Med Mycol Assunto da revista: MEDICINA VETERINARIA / MICROBIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: França País de publicação: Reino Unido