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A first insight into tuberculosis transmission at the border of Ecuador and Colombia: a retrospective study of the population structure of Mycobacterium tuberculosis in Esmeraldas province.
Castro-Rodriguez, Bernardo; Espinoza-Andrade, Sebastián; Franco-Sotomayor, Greta; Benítez-Medina, José Manuel; Jiménez-Pizarro, Natalia; Cárdenas-Franco, Camilo; Granda, Juan Carlos; Jouvin, Jose Luis; Orlando, Solon Alberto; Hermoso de Mendoza, Javier; García-Bereguiain, Miguel Ángel.
Afiliação
  • Castro-Rodriguez B; One Health Research Group, Universidad de las Américas, Quito, Ecuador.
  • Espinoza-Andrade S; One Health Research Group, Universidad de las Américas, Quito, Ecuador.
  • Franco-Sotomayor G; Instituto Nacional de Investigación en Salud Pública "Leopoldo Izquieta Pérez", Guayaquil, Ecuador.
  • Benítez-Medina JM; Facultad de Medicina, Universidad Católica Santiago de Guayaquil, Guayaquil, Ecuador.
  • Jiménez-Pizarro N; Departamento de Patología Infecciosa, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
  • Cárdenas-Franco C; Departamento de Patología Infecciosa, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
  • Granda JC; Facultad de Medicina, Universidad Católica Santiago de Guayaquil, Guayaquil, Ecuador.
  • Jouvin JL; Instituto Nacional de Investigación en Salud Pública "Leopoldo Izquieta Pérez", Guayaquil, Ecuador.
  • Orlando SA; Facultad de Medicina, Universidad Católica Santiago de Guayaquil, Guayaquil, Ecuador.
  • Hermoso de Mendoza J; Instituto Nacional de Investigación en Salud Pública "Leopoldo Izquieta Pérez", Guayaquil, Ecuador.
  • García-Bereguiain MÁ; Universidad Espíritu Santo, Guayaquil, Ecuador.
Front Public Health ; 12: 1343350, 2024.
Article em En | MEDLINE | ID: mdl-38384875
ABSTRACT

Objective:

Tuberculosis (TB) is a major public health concern in Ecuador and Colombia, considering that both countries are high-burden TB settings. Molecular epidemiology is crucial to understand the transmission dynamics of Mycobacterium tuberculosis complex (MTBC) and to identify active transmission clusters of regional importance.

Methods:

We studied the potential transmission of TB between Colombia and Ecuador through the analysis of the population structure of MTBC lineages circulating in the Ecuadorian province of Esmeraldas at the border with Colombia. A total of 105 MTBC strains were characterized by 24-loci MIRU-VNTR and spoligotyping.

Results:

MTBC lineage 4 is only present in Esmeraldas; no MTBC strains belonging to Lineage 2-sublineage Beijing were found despite its presence in other provinces of Ecuador and, in Colombia. Genotyping results revealed a high degree of diversity for MTBC in Esmeraldas Neither active transmission clusters within this province nor including MTBC strains from Colombia or other provinces of Ecuador were found.

Conclusion:

Our data suggest that tuberculosis dynamics in this rural and isolated area may be not related to highly transmitted strains but could be influenced by other health determinants that favor TB relapse such as poverty and poor health system access. Further studies including a larger number of MTBC strains from Esmeraldas are necessary to test this hypothesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Mycobacterium tuberculosis Limite: Humans País/Região como assunto: America do sul / Colombia / Ecuador Idioma: En Revista: Front Public Health Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Equador País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Mycobacterium tuberculosis Limite: Humans País/Região como assunto: America do sul / Colombia / Ecuador Idioma: En Revista: Front Public Health Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Equador País de publicação: Suíça