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Electrostimulable polymeric films with hyaluronic acid and lipid nanoparticles for simultaneous topical delivery of macromolecules and lipophilic drugs.
Martin, Bianca Aparecida; Dalmolin, Luciana Facco; Lemos, Camila Nunes; de Menezes Vaidergorn, Miguel; da Silva Emery, Flavio; Vargas-Rechia, Carem Gledes; Ramos, Ana Paula; Lopez, Renata F V.
Afiliação
  • Martin BA; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida Professor Doutor Zeferino Vaz, s/n, Ribeirão Preto, São Paulo, 14040-903, Brazil.
  • Dalmolin LF; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida Professor Doutor Zeferino Vaz, s/n, Ribeirão Preto, São Paulo, 14040-903, Brazil.
  • Lemos CN; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida Professor Doutor Zeferino Vaz, s/n, Ribeirão Preto, São Paulo, 14040-903, Brazil.
  • de Menezes Vaidergorn M; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida Professor Doutor Zeferino Vaz, s/n, Ribeirão Preto, São Paulo, 14040-903, Brazil.
  • da Silva Emery F; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida Professor Doutor Zeferino Vaz, s/n, Ribeirão Preto, São Paulo, 14040-903, Brazil.
  • Vargas-Rechia CG; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida Professor Doutor Zeferino Vaz, s/n, Ribeirão Preto, São Paulo, 14040-903, Brazil.
  • Ramos AP; Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14040-901, Brazil.
  • Lopez RFV; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida Professor Doutor Zeferino Vaz, s/n, Ribeirão Preto, São Paulo, 14040-903, Brazil. rvianna@fcfrp.usp.br.
Drug Deliv Transl Res ; 14(9): 2499-2519, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38381316
ABSTRACT
This study focused on developing electrically stimulable hyaluronic acid (HA) films incorporating lipid nanoparticles (NPs) designed for the topical administration of lipophilic drugs and macromolecules. Based on beeswax and medium-chain triglycerides, NPs were successfully integrated into silk fibroin/chitosan films containing HA (NP-HA films) at a density of approximately 1011 NP/cm2, ensuring a uniform distribution. This integration resulted in a 40% increase in film roughness, a twofold decrease in Young's modulus, and enhanced film flexibility and bioadhesion work. The NP-HA films, featuring Ag/AgCl electrodes, demonstrated the capability to conduct a constant electrical current of 0.2 mA/cm2 without inducing toxicity in keratinocytes and fibroblasts during a 15-min application. Moreover, the NPs facilitated the homogeneous distribution of lipophilic drugs within the film, effectively transporting them to the skin and uniformly distributing them in the stratum corneum upon film administration. The sustained release of HA from the films, following Higuchi kinetics, did not alter the macroscopic characteristics of the film. Although anodic iontophoresis did not noticeably affect the release of HA, it did enhance its penetration into the skin. This enhancement facilitated the permeation of HA with a molecular weight (MW) of up to 2 × 105 through intercellular and transcellular routes. Confocal Raman spectroscopy provided evidence of an approximate 100% increase in the presence of HA with a MW in the range of 1.5-1.8 × 106 in the viable epidermis of human skin after only 15 min of iontophoresis applied to the films. Combining iontophoresis with NP-HA films exhibits substantial potential for noninvasive treatments focused on skin rejuvenation and wound healing.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Ácido Hialurônico Limite: Animals / Humans Idioma: En Revista: Drug Deliv Transl Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Ácido Hialurônico Limite: Animals / Humans Idioma: En Revista: Drug Deliv Transl Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos