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Identification of genomic regions and pathways associated with traits related to rumen acidosis in feedlot Nellore cattle.
Estevam, Daniela D; Souza, Johnny M; Rey, Fernando S B; Martins, Cyntia L; Stafuzza, Nedenia B; Espigolan, Rafael; Millen, Danilo D; Arrigoni, Mario D B.
Afiliação
  • Estevam DD; Department of Animal Production, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
  • Souza JM; Department of Animal Science, College of Technology and Agricultural Sciences, São Paulo State University (UNESP), Dracena, São Paulo, Brazil.
  • Rey FSB; Department of Animal Science, School of Agricultural and Veterinary Studies, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.
  • Martins CL; Department of Animal Production, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
  • Stafuzza NB; Department of Animal Science, Animal Science Institute (IZ), São Paulo's Agency for Agribusiness Technology (APTA), Sertãozinho, São Paulo, Brazil.
  • Espigolan R; Department of Animal Science and Biological Sciences (DZCB), Federal University of Santa Maria (UFSM), Palmeira das Missões, Brazil.
  • Millen DD; Department of Animal Science, College of Technology and Agricultural Sciences, São Paulo State University (UNESP), Dracena, São Paulo, Brazil.
  • Arrigoni MDB; Department of Animal Production, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
J Anim Breed Genet ; 141(5): 491-506, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38375946
ABSTRACT
There may be an increased risk of metabolic disorders, such as rumen acidosis, in cattle fed high-concentrate diets, particularly those from Bos taurus indicus genotypes, which have shown to be more sensitive to ruminal acidification. Therefore, this study aimed to estimate (co)variance components and identify genomic regions and pathways associated with ruminal acidosis in feedlot Nellore cattle fed high-concentrate diets. It was utilized a dataset containing a total of 642 Nellore bulls that were genotyped from seven feedlot nutrition studies. The GGP Indicus 35k panel was used with the single step genome-wide association study methodology in which the effects of the markers were obtained from the genomic values estimated by the GBLUP model. A bivariate model to estimate genetic correlations between the economically important traits and indicator traits for acidosis was used. The traits evaluated in this study that were nutritionally related to rumen acidosis included average daily gain (ADG), final body weight, time spent eating (TSE), time spent ruminating, rumenitis score (RUM), rumen absorptive surface area (ASA), rumen keratinized layer thickness (KER) and hot carcass weight (HCW). The identified candidate genes were mainly involved in the negative or non-regulation of the apoptotic process, salivary secretion, and transmembrane transport. The genetic correlation between HCW and ASA was low positive (0.27 ± 0.23), and between ADG and ASA was high moderate (0.58 ± 0.59). A positive genetic correlation between RUM and all performance traits was observed, and TSE correlated negatively with HCW (-0.33 ± 0.21), ASA (-0.75 ± 0.48), and KER (-0.40 ± 0.27). The genetic association between economically important traits and indicator traits for acidosis suggested that Nellore cattle may be more sensitive to acidosis in feedlot systems.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rúmen / Acidose / Doenças dos Bovinos Limite: Animals Idioma: En Revista: J Anim Breed Genet Assunto da revista: GENETICA / MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rúmen / Acidose / Doenças dos Bovinos Limite: Animals Idioma: En Revista: J Anim Breed Genet Assunto da revista: GENETICA / MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha