Your browser doesn't support javascript.
loading
Effect of Cucurbita ficifolia Bouché on glutathione level and glycosylated hemoglobin percentage in a Mexican rural population with type 2 diabetes.
Hernandez-Mixteco, Margarita; Bernal-Morales, Blandina; Valenzuela, Olga Lidia; Rodríguez-Landa, Juan Francisco; Cerna-Cortes, Jorge Francisco; García-Montalvo, Eliud Alfredo.
Afiliação
  • Hernandez-Mixteco M; Programa de Doctorado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico. Electronic address: magohdez.m94@gmail.com.
  • Bernal-Morales B; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico. Electronic address: bbernal@uv.mx.
  • Valenzuela OL; Facultad de Ciencias Químicas, Universidad Veracruzana, Orizaba, Veracruz, Mexico. Electronic address: ovalenzuela@uv.mx.
  • Rodríguez-Landa JF; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico. Electronic address: juarodriguez@uv.mx.
  • Cerna-Cortes JF; Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico. Electronic address: jcernac@ipn.mx.
  • García-Montalvo EA; Facultad de Ciencias Químicas, Universidad Veracruzana, Orizaba, Veracruz, Mexico. Electronic address: elagarcia@uv.mx.
J Ethnopharmacol ; 326: 117924, 2024 May 23.
Article em En | MEDLINE | ID: mdl-38369067
ABSTRACT
ETHNOPHARMACOLOGICAL IMPORTANCE Cucurbita ficifolia Bouché fruit is widely used in Mexican traditional medicine to treat type 2 diabetes (T2D) because it has been attributed with antioxidant and hypoglycemic properties in different experimental models and T2D patients. An imbalance in physiological glutathione (GSH) concentrations increases the susceptibility to developing complications associated with oxidative stress in T2D patients. AIM OF THE STUDY To investigate the effect of C. ficifolia on the antioxidant properties of GSH, general health measurements, and biochemical parameters in a Mexican rural population, and to evaluate the changes in socio-affective scores of patients due to improvement in T2D. MATERIALS AND

METHODS:

Twenty-seven women diagnosed with T2D with poor glycemic control volunteered and were divided into two groups C. ficifolia (0.5 g/kg of fresh pulp weight) with hypoglycemic pharmacotherapy, and another group with only hypoglycemic pharmacotherapy, for 12 weeks. We evaluated the effect of the fresh pulp of C. ficifolia on body mass index, blood pressure, glucose, glycosylated hemoglobin, cholesterol, triglycerides, and GSH. Expanding the study, we evaluated the quality of life, anxiety, and depression scores before and after the intervention.

RESULTS:

Treatment with the fresh pulp of C. ficifolia for 12 weeks reduced glycosylated hemoglobin, similar to the hypoglycemic pharmacotherapy group, and significantly increased GSH concentrations. The patients' moods did not change despite increased GSH concentrations and improved T2D control.

CONCLUSIONS:

The increased GSH concentrations due to the consumption of fresh pulp of C. ficifolia could help to protect against oxidative stress and extend therapeutic benefits in addition to the usual hypoglycemic drugs in patients with T2D.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cucurbita / Diabetes Mellitus Tipo 2 Limite: Female / Humans País/Região como assunto: Mexico Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2024 Tipo de documento: Article País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cucurbita / Diabetes Mellitus Tipo 2 Limite: Female / Humans País/Região como assunto: Mexico Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2024 Tipo de documento: Article País de publicação: Irlanda