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Early exposure to trans fat causes cognitive impairment by modulating the expression of proteins associated with oxidative stress and synaptic plasticity in Drosophila melanogaster.
Meichtry, Luana Barreto; Sotelo, Magna Barrientos; Musachio, Elize Aparecida Santos; Janner, Dieniffer Espinosa; Dahleh, Mustafa Munir Mustafa; Fernandes, Eliana Jardim; Bortolotto, Vandreza Cardoso; Guerra, Gustavo Petri; Prigol, Marina.
Afiliação
  • Meichtry LB; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
  • Sotelo MB; Institute of Food Science and Technology, Federal University of Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil.
  • Musachio EAS; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
  • Janner DE; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
  • Dahleh MMM; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
  • Fernandes EJ; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
  • Bortolotto VC; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
  • Guerra GP; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Campus Itaqui, 97650-000 Itaqui, RS, Brazil.
  • Prigol M; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Campus Itaqui, 97650-000 Itaqui, RS, Brazil. Electronic address: marinaprigol@gmail.com.
Comp Biochem Physiol C Toxicol Pharmacol ; 279: 109858, 2024 May.
Article em En | MEDLINE | ID: mdl-38369039
ABSTRACT
Evidence has shown that consuming trans fatty acids (TFA) during development leads to their incorporation into the nervous tissue, resulting in neurological changes in flies. In this study, Drosophila melanogaster was exposed to different concentrations of hydrogenated vegetable fat (HVF) during development substitute hydrogenated vegetable fat (SHVF), HVF 10 %, and HVF 20 %. The objective was to evaluate the effects of early trans fat exposure on cognition and associated pathways in flies. The results showed that early TFA exposure provoked a cerebral redox imbalance, as confirmed by increased reactive species (HVF 10 and 20 %) and lipid peroxidation (SHVF, HVF 10, and 20 %), reduced nuclear factor erythroid 2-related factor 2 immunoreactivity (HVF 10 and 20 %), and increased heat shock protein 70 (HVF 20 %), which was possibly responsible for decreasing superoxide dismutase (SHVF, HVF 10, and 20 %) and catalase (HVF 20 %) activities. Furthermore, the presence of TFA in nervous tissue impaired learning (HVF 10 and 20 %) and memory at 6 and 24 h (SHVF, HVF 10, and 20 %). These cognitive impairments may be linked to reduced Shank levels (HVF 20 %) and increased acetylcholinesterase activity (SHVF, HVF 10 and 20 %) observed. Our findings demonstrate that early exposure to trans fat leads to cerebral redox imbalance, altering proteins associated with stress, synaptic plasticity, and the cholinergic system, consequently leading to cognitive impairment in flies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Graxos trans / Disfunção Cognitiva Limite: Animals Idioma: En Revista: Comp Biochem Physiol C Toxicol Pharmacol Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Graxos trans / Disfunção Cognitiva Limite: Animals Idioma: En Revista: Comp Biochem Physiol C Toxicol Pharmacol Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos