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Strength training improves heart function, collagen and strength in rats with heart failure.
Dias, Leisiane G; Reis, Carlos H O; Dos Santos, Leonardo; Krause Neto, Walter; Lima-Leopoldo, Ana Paula; Baker, Julien S; Leopoldo, André S; Bocalini, Danilo S.
Afiliação
  • Dias LG; Experimental Physiology and Biochemistry Laboratory. Physical Education and Sport Center, Federal University of Espirito Santo, Vitoria, Brazil.
  • Reis CHO; Experimental Physiology and Biochemistry Laboratory. Physical Education and Sport Center, Federal University of Espirito Santo, Vitoria, Brazil.
  • Dos Santos L; Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Brazil.
  • Krause Neto W; Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil.
  • Lima-Leopoldo AP; Experimental Physiology and Biochemistry Laboratory. Physical Education and Sport Center, Federal University of Espirito Santo, Vitoria, Brazil.
  • Baker JS; Department of Sport, Physical Education and Health, Centre for Health and Exercise Science Research, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
  • Leopoldo AS; Experimental Physiology and Biochemistry Laboratory. Physical Education and Sport Center, Federal University of Espirito Santo, Vitoria, Brazil.
  • Bocalini DS; Experimental Physiology and Biochemistry Laboratory. Physical Education and Sport Center, Federal University of Espirito Santo, Vitoria, Brazil. bocaliniht@hotmail.com.
J Physiol Sci ; 74(1): 10, 2024 Feb 16.
Article em En | MEDLINE | ID: mdl-38365576
ABSTRACT
BACKGROUND/

OBJECTIVES:

Myocardial infarction (MI) frequently leads to cardiac remodeling and failure with impaired life quality, playing an important role in cardiovascular deaths. Although physical exercise is a well-recognized effective non-pharmacological therapy for cardiovascular diseases, the effects of strength training (ST) on the structural and functional aspects of cardiac remodeling need to be further documented. In this study, we aimed to investigate the role of a linear block ST protocol in the rat model of MI. METHODS AND

RESULTS:

After 6 weeks of MI induction or sham surgery, male adult rats performed ST for the following 12 weeks. The ladder-based ST program was organized in three mesocycles of 4 weeks, with one load increment for each block according to the maximal carrying load test. After 12 weeks, the infarcted-trained rats exhibited an increase in performance, associated with reduced cardiac hypertrophy and pulmonary congestion compared with the untrained group. Despite not changing MI size, the ST program partially prevented cardiac dilatation and ventricular dysfunction assessed by echocardiography and hemodynamics, and interstitial fibrosis evaluated by histology. In addition, isolated cardiac muscles from infarcted-trained rats had improved contractility parameters in a steady state, and in response to calcium or stimuli pauses.

CONCLUSIONS:

The ST in infarcted rats increased the capacity to carry mass, associated with attenuation of cardiac remodeling and pulmonary congestion with improving cardiac function that could be attributed, at least in part, to the improvement of myocardial contractility.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Treinamento Resistido / Insuficiência Cardíaca / Infarto do Miocárdio Limite: Animals / Humans / Male Idioma: En Revista: J Physiol Sci Assunto da revista: FISIOLOGIA / TRAUMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Treinamento Resistido / Insuficiência Cardíaca / Infarto do Miocárdio Limite: Animals / Humans / Male Idioma: En Revista: J Physiol Sci Assunto da revista: FISIOLOGIA / TRAUMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Japão