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Cortical folding correlates to aging and Alzheimer's Disease's cognitive and CSF biomarkers.
de Moraes, Fernanda Hansen P; Sudo, Felipe; Carneiro Monteiro, Marina; de Melo, Bruno R P; Mattos, Paulo; Mota, Bruno; Tovar-Moll, Fernanda.
Afiliação
  • de Moraes FHP; Brain Connectivity Unit, D'Or Institute of Research and Education (IDOR), Rio de Janeiro, 225281-100, Brazil.
  • Sudo F; Instituto de Física, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, 21941-909, Brazil.
  • Carneiro Monteiro M; Memory Clinic, D'Or Institute of Research and Education (IDOR), Rio de Janeiro, 225281-100, Brazil.
  • de Melo BRP; Brain Connectivity Unit, D'Or Institute of Research and Education (IDOR), Rio de Janeiro, 225281-100, Brazil.
  • Mattos P; Brain Connectivity Unit, D'Or Institute of Research and Education (IDOR), Rio de Janeiro, 225281-100, Brazil.
  • Mota B; Memory Clinic, D'Or Institute of Research and Education (IDOR), Rio de Janeiro, 225281-100, Brazil.
  • Tovar-Moll F; Instituto de Física, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, 21941-909, Brazil.
Sci Rep ; 14(1): 3222, 2024 02 08.
Article em En | MEDLINE | ID: mdl-38332140
ABSTRACT
This manuscript presents the quantification and correlation of three aspects of Alzheimer's Disease evolution, including structural, biochemical, and cognitive assessments. We aimed to test a novel structural biomarker for neurodegeneration based on a cortical folding model for mammals. Our central hypothesis is that the cortical folding variable, representative of axonal tension in white matter, is an optimal discriminator of pathological aging and correlates with altered loadings in Cerebrospinal Fluid samples and a decline in cognition and memory. We extracted morphological features from T1w 3T MRI acquisitions using FreeSurfer from 77 Healthy Controls (age = 66 ± 8.4, 69% females), 31 Mild Cognitive Impairment (age = 72 ± 4.8, 61% females), and 13 Alzheimer's Disease patients (age = 77 ± 6.1, 62% females) of recruited volunteers in Brazil to test its discriminative power using optimal cut-point analysis. Cortical folding distinguishes the groups with reasonable accuracy (Healthy Control-Alzheimer's Disease, accuracy = 0.82; Healthy Control-Mild Cognitive Impairment, accuracy = 0.56). Moreover, Cerebrospinal Fluid biomarkers (total Tau, A[Formula see text]1-40, A[Formula see text]1-42, and Lipoxin) and cognitive scores (Cognitive Index, Rey's Auditory Verbal Learning Test, Trail Making Test, Digit Span Backward) were correlated with the global neurodegeneration in MRI aiming to describe health, disease, and the transition between the two states using morphology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido