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COMT and SCN9A gene variants do not contribute to chronic low back pain in Mexican-Mestizo patients.
Nava-Bringas, Tania Inés; Manrique, Carlos Manuel Juaristi; González-Huerta, Norma Celia; Morales-Hernández, Eugenio; Miranda-Duarte, Antonio.
Afiliação
  • Nava-Bringas TI; Department of Orthopedic Rehabilitation, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Av. México-Xochimilco 289, Colonia Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico.
  • Manrique CMJ; Department of Genomic Medicine, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Av. México-Xochimilco 289, Colonia Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico.
  • González-Huerta NC; Department of Genomic Medicine, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Av. México-Xochimilco 289, Colonia Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico.
  • Morales-Hernández E; Radiology Service, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Av. México-Xochimilco 289, Colonia Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico.
  • Miranda-Duarte A; Department of Genomic Medicine, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Av. México-Xochimilco 289, Colonia Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico. antoniomirandaduarte@gmail.com.
Acta Neurochir (Wien) ; 166(1): 73, 2024 Feb 08.
Article em En | MEDLINE | ID: mdl-38329587
ABSTRACT

BACKGROUND:

Chronic low back pain (CLBP) is a complex condition in which genetic factors play a role in its susceptibility. Catechol-O-methyltransferase (COMT) and sodium channel NaV1.7 (SCN9A) genes are implicated in pain perception. The aim is to analyze the association of COMT and SCN9A with CLBP and their interaction, in a Mexican-Mestizo population.

METHODS:

A case-control study was conducted. Cases corresponded to adults of both sexes with CLBP. Controls were adults with no CLBP. Variants of SCN9A and COMT were genotyped. Allelic and genotypic frequencies and Hardy-Weinberg equilibrium (HWE) were calculated. Association was tested under codominant, dominant, and recessive models. Multifactor dimensionality reduction was developed to detect epistasis.

RESULTS:

Gene variants were in HWE, and there was no association under different inheritance models in the whole sample. In women, in codominant and dominant models, a trend to a high risk was observed for AA of rs4680 of COMT (OR = 1.7 [0.5-5.3] and 1.6 [0.7-3.4]) and for TT of rs4633 (OR = 1.6 [0.7-3.7] and 1.6 [0.7-3.4]). In men, a trend to low risk was observed for AG genotype of rs4680 in the same models (OR = 0.6 [0.2-1.7] and 0.7 [0.3-1.7]), and for TC genotype of rs4633 in the codominant model (OR = 0.6 [0.2-1.7]). In the interaction analysis, a model of the SCN9A and COMT variants showed a CVC of 10/10; however, the TA was 0.4141.

CONCLUSION:

COMT and SCN9A variants are not associated with CLBP in the analyzed Mexican-Mestizo population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catecol O-Metiltransferase / Dor Lombar / Canal de Sódio Disparado por Voltagem NAV1.7 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Acta Neurochir (Wien) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Áustria
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catecol O-Metiltransferase / Dor Lombar / Canal de Sódio Disparado por Voltagem NAV1.7 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Acta Neurochir (Wien) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Áustria