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Effects of Solanum tuberosum L. ointment on second-degree burns in mice.
Silva-Correa, Carmen R; Rosas-Cruz, Galy P; Calderón-Peña, Abhel A; Torre, Víctor E Villarreal-La; Aspajo-Villalaz, Cinthya L; Castañeda-Carranza, Julio A; Dionicio-Rosado, Deivy Y; Gómez-Arce, Ricardo M; Rodríguez-Silva, Cristhian N; Rosario-Chávarri, Jorge Del; Cruzado-Razco, José L.
Afiliação
  • Silva-Correa CR; Department of Pharmacology, Faculty of Pharmacy and Biochemistry, National University of Trujillo, Peru.
  • Rosas-Cruz GP; Department of Pharmacology, Faculty of Pharmacy and Biochemistry, National University of Trujillo, Peru.
  • Calderón-Peña AA; Department of Biological Chemistry and Animal Physiology, Faculty of Biological Sciences, National University of Trujillo, Peru.
  • Torre VEV; Department of Pharmacology, Faculty of Pharmacy and Biochemistry, National University of Trujillo, Peru.
  • Aspajo-Villalaz CL; Department of Biological Chemistry and Animal Physiology, Faculty of Biological Sciences, National University of Trujillo, Peru.
  • Castañeda-Carranza JA; Professional Department of Statistics, Faculty of Physical Sciences and Mathematics, National University of Trujillo, Peru.
  • Dionicio-Rosado DY; Professional Department of Statistics, Faculty of Physical Sciences and Mathematics, National University of Trujillo, Peru.
  • Gómez-Arce RM; Professional Department of Statistics, Faculty of Physical Sciences and Mathematics, National University of Trujillo, Peru.
  • Rodríguez-Silva CN; Department of Biological Chemistry and Animal Physiology, Faculty of Biological Sciences, National University of Trujillo, Peru.
  • Rosario-Chávarri JD; Department of Biological Chemistry and Animal Physiology, Faculty of Biological Sciences, National University of Trujillo, Peru.
  • Cruzado-Razco JL; Department of Pharmacology, Faculty of Pharmacy and Biochemistry, National University of Trujillo, Peru.
Vet World ; 16(12): 2440-2445, 2023 Dec.
Article em En | MEDLINE | ID: mdl-38328356
ABSTRACT
Background and

Aim:

Potato (Solanum tuberosum L.) is mainly characterized by its antioxidant and healing properties. Therefore, this study aimed to evaluate the effects of an ointment based on S. tuberosum L. "papa tumbay" on burns induced in Balb/c mice (Mus musculus). Materials and

Methods:

The experimental animals were divided into four groups (n = 5/group) 48 h before second-degree burns were inducted. After epilating the loin areas of the mice and anesthetizing them with ketamine/xylazine (80 mg/kg/10 mg/kg) through intraperitoneal (i.p.) route, a round metal rod (0.7 cm in diameter) was placed on the depilated skin at a temperature of 100°C for 5 s. Group I was not given any treatment, Group II was treated with silver sulfadiazine (1%), and the other two groups (III and IV) were treated with the ointment formulated based on S. tuberosum L. "papa tumbay" at 1% and 2%, respectively. After performing the treatment for 21 days, the mice were euthanized using i.p. sodium pentobarbital (185 mg/kg) to obtain skin samples. The samples were preserved in 10% neutral-buffered formalin and subjected to histopathological analysis.

Results:

We found statistically significant differences in the histopathological sections between the groups (p < 0.05). The abundant collagen and fibroblasts observed in the direction of the dermis in Groups III and IV indicate that the phytoconstituents present in the potato might promote the healing of the second-degree burns until day 21 of treatment.

Conclusion:

Our findings showed that the ointments based on the ethanolic extracts of S. tuberosum L. "papa tumbay," especially the 2% ointment, might accelerate the healing of second-degree burns induced in Balb/c mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Vet World Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Peru País de publicação: Índia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Vet World Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Peru País de publicação: Índia