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Clinical outcomes and manometry results of peroral endoscopic myotomy in patients with achalasia: experience in a Latin American referral centre. / Resultados clínicos y manométricos de la miotomía endoscópica peroral en pacientes con acalasia: experiencia en un centro de referencia latinoamericano.
Tobón, Angélica; Cantillo Nassar, Gustavo Rafael; Hani, Albis Cecilia; Herrera Leaño, Nancy Muriel; Pulgarin, Cristiam; Muñoz, Oscar Mauricio.
Afiliação
  • Tobón A; Departamento de Gastroenterología, Pontificia Universidad Javeriana, Bogotá, Colombia. Electronic address: angelica.tobong@javeriana.edu.co.
  • Cantillo Nassar GR; Departamento de Gastroenterología, Pontificia Universidad Javeriana, Bogotá, Colombia.
  • Hani AC; Departamento de Gastroenterología y Endoscopia Digestiva, Hospital Universitario San Ignacio, Bogotá, Colombia.
  • Herrera Leaño NM; Departamento de Cardiología, Pontificia Universidad Javeriana, Bogotá, Colombia.
  • Pulgarin C; Departamento de Gastroenterología, Pontificia Universidad Javeriana, Bogotá, Colombia.
  • Muñoz OM; Departamento de Medicina Interna, Hospital Universitario San Ignacio, Bogotá, Colombia.
Gastroenterol Hepatol ; 47(7): 734-741, 2024.
Article em En, Es | MEDLINE | ID: mdl-38316173
ABSTRACT

INTRODUCTION:

Currently there is little information in Latin America on the clinical outcome and manometric evolution of patients with Achalasia undergoing peroral endoscopic myotomy (POEM). PRIMARY

OUTCOME:

Evaluate the manometric and clinical changes in adult patients with achalasia after peroral endoscopic myotomy at a referral center in Bogotá, Colombia.

METHODS:

Observational, analytical, longitudinal study. Adult patients with achalasia according to the Chicago 4.0 criteria were included. Sociodemographic, clinical and manometric variables were described. To compare the pre- and post-surgical variables, the Student's or Wilcoxon's t test was used for the quantitative variables according to their normality, and McNemar's chi-square for the qualitative variables.

RESULTS:

29 patients were included, 55.17% (n=16) women, with a mean age at the time of surgery of 48.2 years (±11.33). The mean post-procedure evaluation time was 1.88±0.81 years. After the procedure, there was a significant decrease in the proportion of patients with weight loss (37.93% vs 21.43% p 0.0063), chest pain (48.28% vs 21.43, p 0.0225) and the median Eckardt score (8 (IQR 8 -9) vs 2(IQR 1-2), p <0.0001). In addition, in fourteen patients with post-surgical manometry, significant differences were found between IRP values (23.05±14.83mmHg vs 7.69±6.06mmHg, p 0.026) and in the mean lower esophageal sphincter tone (9.63±7.2mmHg vs 28.8±18.60mmHg, p 0.0238).

CONCLUSION:

Peroral endoscopic myotomy has a positive impact on the improvement of symptoms and of some manometric variables (IRP and LES tone) in patients with achalasia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acalasia Esofágica / Cirurgia Endoscópica por Orifício Natural / Manometria Tipo de estudo: Observational_studies / Qualitative_research Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En / Es Revista: Gastroenterol Hepatol Ano de publicação: 2024 Tipo de documento: Article País de publicação: Espanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acalasia Esofágica / Cirurgia Endoscópica por Orifício Natural / Manometria Tipo de estudo: Observational_studies / Qualitative_research Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En / Es Revista: Gastroenterol Hepatol Ano de publicação: 2024 Tipo de documento: Article País de publicação: Espanha