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Genomic epidemiology and antifungal-resistant characterization of Candida auris, Colombia, 2016-2021.
Misas, Elizabeth; Escandón, Patricia L; Gade, Lalitha; Caceres, Diego H; Hurst, Steve; Le, Ngoc; Min, Brian; Lyman, Meghan; Duarte, Carolina; Chow, Nancy A.
Afiliação
  • Misas E; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Escandón PL; Grupo de Microbiología, Instituto Nacional de Salud, Bogotá, Colombia.
  • Gade L; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Caceres DH; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Hurst S; Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, the Netherlands.
  • Le N; Studies in Translational Microbiology and Emerging Diseases (MICROS) Research Group, School ofMedicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.
  • Min B; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Lyman M; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Duarte C; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Chow NA; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
mSphere ; 9(2): e0057723, 2024 Feb 28.
Article em En | MEDLINE | ID: mdl-38299868
ABSTRACT
Since 2016, in Colombia, ongoing transmission of Candida auris has been reported in multiple cities. Here, we provide an updated description of C. auris genomic epidemiology and the dynamics of antifungal resistance in Colombia. We sequenced 99 isolates from C. auris cases with collection dates ranging from June 2016 to January 2021; the resulting sequences coupled with 103 previously generated sequences from C. auris cases were described in a phylogenetic analysis. All C. auris cases were clade IV. Of the 182 isolates with antifungal susceptibility data, 67 (37%) were resistant to fluconazole, and 39 (21%) were resistant to amphotericin B. Isolates predominately clustered by country except for 16 isolates from Bogotá, Colombia, which grouped with isolates from Venezuela. The largest cluster (N = 166 isolates) contained two subgroups. The first subgroup contained 26 isolates, mainly from César; of these, 85% (N = 22) were resistant to fluconazole. The second subgroup consisted of 47 isolates from the north coast; of these, 81% (N = 38) were resistant to amphotericin B. Mutations in the ERG11 and TAC1B genes were identified in fluconazole-resistant isolates. This work describes molecular mechanisms associated with C. auris antifungal resistance in Colombia. Overall, C. auris cases from different geographic locations in Colombia exhibited high genetic relatedness, suggesting continued transmission between cities since 2016. These findings also suggest a lack of or minimal introductions of different clades of C. auris into Colombia. IMPORTANCE Candida auris is an emerging fungus that presents a serious global health threat and has caused multiple outbreaks in Colombia. This work discusses the likelihood of introductions and local transmission of C. auris and provides an updated description of the molecular mechanisms associated with antifungal resistance in Colombia. Efforts like this provide information about the evolving C. auris burden that could help guide public health strategies to control C. auris spread.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candidíase / Antifúngicos Tipo de estudo: Prognostic_studies / Screening_studies Limite: Humans País/Região como assunto: America do sul / Colombia Idioma: En Revista: MSphere Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candidíase / Antifúngicos Tipo de estudo: Prognostic_studies / Screening_studies Limite: Humans País/Região como assunto: America do sul / Colombia Idioma: En Revista: MSphere Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos