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Zein and hydroxypropyl methylcellulose acetate succinate microfibers combined with metronidazole benzoate and/or metronidazole-incorporated cellulose nanofibrils for potential periodontal treatment.
Ferreira, João O; Zambuzi, Giovana C; Camargos, Camilla H M; Carvalho, Ana C W; Ferreira, Maíra P; Rezende, Camila A; de Freitas, Osvaldo; Francisco, Kelly R.
Afiliação
  • Ferreira JO; Science and Technology Center for Sustainability, Federal University of São Carlos, Rod. SP-264, km 110, Sorocaba 18052-780, SP, Brazil.
  • Zambuzi GC; Science and Technology Center for Sustainability, Federal University of São Carlos, Rod. SP-264, km 110, Sorocaba 18052-780, SP, Brazil.
  • Camargos CHM; Department of Physical Chemistry, Institute of Chemistry, University of Campinas, 13083-970 Campinas, SP, Brazil; School of Fine Arts, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
  • Carvalho ACW; Department of Pharmaceutical Sciences, Faculty of Pharmaceuticals Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040-903, SP, Brazil.
  • Ferreira MP; Department of Pharmaceutical Sciences, Faculty of Pharmaceuticals Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040-903, SP, Brazil.
  • Rezende CA; Department of Physical Chemistry, Institute of Chemistry, University of Campinas, 13083-970 Campinas, SP, Brazil.
  • de Freitas O; Department of Pharmaceutical Sciences, Faculty of Pharmaceuticals Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040-903, SP, Brazil.
  • Francisco KR; Science and Technology Center for Sustainability, Federal University of São Carlos, Rod. SP-264, km 110, Sorocaba 18052-780, SP, Brazil; Department of Natural Science, Mathematics and Education, Federal University of São Carlos-UFSCar, Araras 13604-900, SP, Brazil. Electronic address: kfrancisco@ufs
Int J Biol Macromol ; 261(Pt 1): 129701, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38280709
ABSTRACT
The development of flexible and porous materials to control antibacterial delivery is a pivotal endeavor in medical science. In this study, we aimed to produce long and defect-free fibers made of zein and hydroxypropyl methylcellulose acetate succinate (HPMCAS) to be used as a platform for the release of metronidazole (MDZ) and metronidazole benzoate (BMDZ) to be potentially used in periodontal treatment. Microfibers prepared via electrospinning under a 23 (w/w) zein to HPMCAS ratio, containing 0.5 % (w/w) poly(ethylene oxide) (PEO) and 1 % (w/w) cellulose nanofibril (CNF) were loaded with 40 % (w/w) MDZ, 40 % (w/w) BMDZ, or a combination of 20 % (w/w) of each drug. The addition of CNF improved the electrospinning process, resulting in long fibers with reduced MDZ and BMDZ surface crystallization. MDZ- and BMDZ-incorporated fibers were semicrystalline and displayed commendable compatibility among drugs, nanocellulose and polymeric chains. Release tests showed that zein/HPMCAS/PEO fibers without CNF and with 20 % (w/w) MDZ/ 20 % (w/w) BMDZ released the drug at a slower and more sustained rate compared to other samples over extended periods (up to 5 days), which is a favorable aspect concerning periodontitis treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zeína / Metilcelulose / Metronidazol Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zeína / Metilcelulose / Metronidazol Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda