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The role of neurotrophin polymorphisms and susceptibility to neural damage in leprosy.
Jorge, Karina Talita de Oliveira Santana; Braga, Marina Pimenta; Cazzaniga, Rodrigo Anselmo; Santos, Camilla Natália Oliveira; Teixeira, Mauro Martins; Gomes, Karina Braga; de Jesus, Amélia Maria Ribeiro; Soriani, Frederico Marianetti.
Afiliação
  • Jorge KTOS; Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Braga MP; Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Cazzaniga RA; Department of Medicine, Federal University of Sergipe, Aracaju, Brazil.
  • Santos CNO; Department of Medicine, Federal University of Sergipe, Aracaju, Brazil.
  • Teixeira MM; Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Gomes KB; Department of Clinical and Toxicological Analyzes - Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • de Jesus AMR; Department of Medicine, Federal University of Sergipe, Aracaju, Brazil.
  • Soriani FM; Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil. Electronic address: fredsori@gmail.com.
Int J Infect Dis ; 142: 106946, 2024 May.
Article em En | MEDLINE | ID: mdl-38278287
ABSTRACT

OBJECTIVES:

Mycobacterium leprae is able to infect Schwann cells leading to neural damage. Neurotrophins are involved in nervous system plasticity and impact neural integrity during diseases. Investigate the association between single nucleotide polymorphisms in neurotrophin genes and leprosy phenotypes, especially neural damage.

DESIGN:

We selected single nucleotide polymorphisms in neurotrophins or their receptors genes associated with neural disorders rs6265 and rs11030099 of brain-derived neurotrophic factor (BDNF), rs6330 of BDNF, rs6332 in NT3 and rs2072446 of P75NTR. The association of genetic frequencies with leprosy phenotypes was investigated in a case-control study.

RESULTS:

An association of the BDNF single nucleotide polymorphism rs11030099 with the number of affected nerves was demonstrated. The "AA+AC" genotypes were demonstrated to be protective against nerve impairment. However, this variation does not affect BDNF serum levels. BDNF is an important factor for myelination of Schwann cells and polymorphisms in this gene can be associated with leprosy outcome. Moreover, rs11030099 is located in the binding region for micro-RNA (miRNA) 26a that could be involved in control of BDNF expression. We demonstrated different expression levels of this miRNA in polar forms of leprosy.

CONCLUSION:

Our findings demonstrate for the first time an association between the polymorphism rs11030099 in the BDNF gene and neural commitment in leprosy and may indicate a possible role of miRNA-26a acting synergistically to these genetic variants in neural damage development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Hanseníase Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Hanseníase Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá