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Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review.
Silva, Vitória R P; Pinheiro, Andréia C; Ombredane, Alicia S; Martins, Natália Ornelas; Luz, Glécia V S; Carneiro, Marcella L B; Joanitti, Graziella A.
Afiliação
  • Silva VRP; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Faculty of Ceilandia, University of Brasilia, Centro Metropolitano, Ceilândia Sul, Brasilia 72220-275, DF, Brazil.
  • Pinheiro AC; Post-Graduate Program in Pharmaceuticals Sciences, Faculty of Health Sciences, University of Brasilia, Campus Darcy Ribeiro, Brasilia 70910-900, DF, Brazil.
  • Ombredane AS; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Faculty of Ceilandia, University of Brasilia, Centro Metropolitano, Ceilândia Sul, Brasilia 72220-275, DF, Brazil.
  • Martins NO; Post-Graduation Program in Nanoscience and Nanobiotechnology, Institute of Biological Sciences, University of Brasilia, Campus Darcy Ribeiro, Brasilia 70910-900, DF, Brazil.
  • Luz GVS; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Faculty of Ceilandia, University of Brasilia, Centro Metropolitano, Ceilândia Sul, Brasilia 72220-275, DF, Brazil.
  • Carneiro MLB; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Faculty of Ceilandia, University of Brasilia, Centro Metropolitano, Ceilândia Sul, Brasilia 72220-275, DF, Brazil.
  • Joanitti GA; Health Technology Assessment Center-NATS/UnB, University of Brasilia, Campus Darcy Ribeiro, Brasilia 70910-900, DF, Brazil.
Pharmaceuticals (Basel) ; 17(1)2023 Dec 21.
Article em En | MEDLINE | ID: mdl-38275996
ABSTRACT
Disorders in the inflammatory process underlie the pathogenesis of numerous diseases. The utilization of natural products as anti-inflammatory agents is a well-established approach in both traditional medicine and scientific research, with studies consistently demonstrating their efficacy in managing inflammatory conditions. Pequi oil, derived from Caryocar brasiliense, is a rich source of bioactive compounds including fatty acids and carotenoids, which exhibit immunomodulatory potential. This systematic review aims to comprehensively summarize the scientific evidence regarding the anti-inflammatory activity of pequi oil. Extensive literature searches were conducted across prominent databases (Scopus, BVS, CINAHL, Cochrane, LILACS, Embase, MEDLINE, ProQuest, PubMed, FSTA, ScienceDirect, and Web of Science). Studies evaluating the immunomodulatory activity of crude pequi oil using in vitro, in vivo models, or clinical trials were included. Out of the 438 articles identified, 10 met the stringent inclusion criteria. These studies collectively elucidate the potential of pequi oil to modulate gene expression, regulate circulating levels of pro- and anti-inflammatory mediators, and mitigate oxidative stress, immune cell migration, and cardinal signs of inflammation. Moreover, negligible to no toxicity of pequi oil was observed across the diverse evaluated models. Notably, variations in the chemical profile of the oil were noted, depending on the extraction methodology and geographical origin. This systematic review strongly supports the utility of pequi oil in controlling the inflammatory process. However, further comparative studies involving oils obtained via different methods and sourced from various regions are warranted to reinforce our understanding of its effectiveness and safety.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Systematic_reviews País/Região como assunto: America do sul / Brasil Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Systematic_reviews País/Região como assunto: America do sul / Brasil Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça