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COVID-19 Crisis in Brazil: Post-Vaccination Seroprevalence and Infection in More and Less Vaccinated Municipalities in a Northeastern State.
Santos, Ronaldy Santana; Barreto, Marina Dos Santos; Silva, Eloia Emanuelly Dias; Silva, Beatriz Soares da; Jesus, Pamela Chaves de; Silva, Deise Maria Rego Rodrigues; Moura, Pedro Henrique Macedo; Souza, Jessiane Bispo de; Santos, Leticia Milena Machado Dos; Guimarães, Adriana Gibara; Santana, Lucas Alves da Mota; Borges, Lysandro Pinto.
Afiliação
  • Santos RS; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
  • Barreto MDS; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
  • Silva EED; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
  • Silva BSD; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
  • Jesus PC; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
  • Silva DMRR; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
  • Moura PHM; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
  • Souza JB; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
  • Santos LMMD; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
  • Guimarães AG; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
  • Santana LADM; Graduate Program in Dentistry, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
  • Borges LP; Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil.
Life (Basel) ; 14(1)2024 Jan 08.
Article em En | MEDLINE | ID: mdl-38255709
ABSTRACT

BACKGROUND:

Given the impact of the pandemic in Brazil, vaccination is essential to prevent illness and death. Thus, this study sought to compare, after vaccination, the circulation of SARS-CoV-2 and the response to vaccination in the least and most vaccinated municipalities of a Brazilian state during the height of the pandemic when the Omicron variant was dominant.

METHODS:

We tested for the SARS-CoV-2 antigen and confirmed infection using an RT-qPCR and measured IgM and IgG antibodies in fully vaccinated participants from municipalities with higher and lower vaccination rates.

RESULTS:

We showed that participants from the least vaccinated municipalities were more likely to have detectable IgM antibodies and a positive antigen/RT-qPCR result for SARS-CoV-2 than participants from the most vaccinated municipalities. There were no differences between the vaccines used (BNT162b2, Ad26.COV2.S, AZD1222, and CoronaVac) and antibody production.

CONCLUSIONS:

Our study evaluated municipal vaccination coverage and its effects on mortality, infections, and anti-SARS-CoV-2 antibodies during a critical phase of the pandemic. The results suggest that higher vaccination coverage reduces acute cases and confers higher memory antibody levels against SARS-CoV-2. Even with a full vaccination schedule, individuals living in places with low vaccination rates are more susceptible to infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Life (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Life (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça