Rate and predictors of insufficient sweat volume in very young infants after pilocarpine gel iontophoresis: prospective, population-based study.
Arch Dis Child
; 109(4): 304-307, 2024 Mar 19.
Article
em En
| MEDLINE
| ID: mdl-38253430
ABSTRACT
OBJECTIVE:
To verify the rate and predictors of 'quantity not sufficient' (QNS) among Brazilian infants younger than 3 months with positive newborn screening (NBS) for cystic fibrosis (CF).DESIGN:
Prospective, population-based study.SETTING:
Public Statewide Newborn Screening Programme where the incidence rate of CF is ≈111 000. PATIENTS Subjects with positive two-tiered immunoreactive trypsinogen.INTERVENTIONS:
Sweat induction and collection were performed in the same facility; one sweat sample was obtained per individual. MAIN OUTCOMEMEASURES:
The QNS rate and its predictors; analysis corresponded to the day of sweat collection.RESULTS:
Among the 975 participants, QNS rates for 10 and 15 µL were 3.6% (95% CI 2.5% to 4.9%) and 8.3% (95% CI 6.6% to 10.2%). Infants weighing >3056 and >3845 g and with gestational age higher than 37 weeks had a greater likelihood (5.5 and 6.7, and 2.7 and 5.8 times more, respectively) of avoiding QNS than their peers.CONCLUSION:
QNS rates fulfilled the requirements, but predictors differed from those recommended by the Cystic Fibrosis Foundations guidelines.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pilocarpina
/
Fibrose Cística
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
Arch Dis Child
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido