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Duchenne and Becker muscular dystrophy: Cellular mechanisms, image analysis, and computational models: A review.
Escobar-Huertas, J F; Vaca-González, Juan Jairo; Guevara, Johana María; Ramirez-Martinez, Angelica M; Trabelsi, Olfa; Garzón-Alvarado, D A.
Afiliação
  • Escobar-Huertas JF; Numerical Methods and Modeling Research Group (GNUM), Universidad Nacional de Colombia, Bogotá, Colombia.
  • Vaca-González JJ; Université de technologie de Compiègne, CNRS, Biomechanics and Bioengineering, Centre de Recherche Royallieu, Compiègne Cedex, France.
  • Guevara JM; Escuela de pregrado, Dirección Académica, Vicerrectoría de Sede, Universidad Nacional de Colombia, Sede la Paz, Cesar, Colombia.
  • Ramirez-Martinez AM; Institute for the Study of Inborn Errors of Metabolism, Pontificia Universidad Javeriana, Bogotá, Colombia.
  • Trabelsi O; Biomedical Engineering Department, Engineering Faculty, Universidad Militar Nueva Granada, Bogotá, Colombia.
  • Garzón-Alvarado DA; Université de technologie de Compiègne, CNRS, Biomechanics and Bioengineering, Centre de Recherche Royallieu, Compiègne Cedex, France.
Cytoskeleton (Hoboken) ; 81(6-7): 269-286, 2024.
Article em En | MEDLINE | ID: mdl-38224155
ABSTRACT
The muscle is the principal tissue that is capable to transform potential energy into kinetic energy. This process is due to the transformation of chemical energy into mechanical energy to enhance the movements and all the daily activities. However, muscular tissues can be affected by some pathologies associated with genetic alterations that affect the expression of proteins. As the muscle is a highly organized structure in which most of the signaling pathways and proteins are related to one another, pathologies may overlap. Duchenne muscular dystrophy (DMD) is one of the most severe muscle pathologies triggering degeneration and muscle necrosis. Several mathematical models have been developed to predict muscle response to different scenarios and pathologies. The aim of this review is to describe DMD and Becker muscular dystrophy in terms of cellular behavior and molecular disorders and to present an overview of the computational models implemented to understand muscle behavior with the aim of improving regenerative therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distrofia Muscular de Duchenne Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cytoskeleton (Hoboken) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distrofia Muscular de Duchenne Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cytoskeleton (Hoboken) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos