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Denture stomatitis: Treatment with antimicrobial drugs or antifungal gels? A systematic review of clinical trials.
Carvalho-Silva, João Marcos; Gaspar, Carol Silva; Dos Reis, Andréa Cândido; Teixeira, Ana Beatriz Vilela.
Afiliação
  • Carvalho-Silva JM; Undergraduate student, Department of Dental Materials and Prosthesis, Ribeirão Preto Dental School, University of São Paulo (USP), Ribeirão Preto, Brazil.
  • Gaspar CS; Graduate student, Department of Dental Materials and Prosthesis, Ribeirão Preto Dental School, University of São Paulo (USP), Ribeirão Preto, Brazil.
  • Dos Reis AC; Associate Professor, Department of Dental Materials and Prosthesis, Ribeirão Preto Dental School, University of São Paulo (USP), Ribeirão Preto, Brazil. Electronic address: andreare73@yahoo.com.br.
  • Teixeira ABV; Postdoctoral student, Department of Dental Materials and Prosthesis, Ribeirão Preto Dental School, University of São Paulo (USP), Ribeirão Preto, Brazil.
J Prosthet Dent ; 2024 Jan 08.
Article em En | MEDLINE | ID: mdl-38195253
ABSTRACT
STATEMENT OF

PROBLEM:

Gel formulations containing antimicrobials are a potential alternative for the development of new medicines for the treatment of denture stomatitis (DS). However, whether they are more effective than antifungal drugs is unclear.

PURPOSE:

The purpose of this systematic review was to identify whether gels formulated with antimicrobial substances are more effective and biocompatible for the treatment of DS than antifungal drugs. MATERIAL AND

METHODS:

This systematic review was structured according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42022379510). Searches were performed in the PubMed, Lilacs, Web of Science, Scopus, Embase, and Google Scholar databases in November 2022. Randomized and nonrandomized clinical trials comparing the efficacy of experimental gels and conventional antifungals in the treatment of DS were included.

RESULTS:

Gels formulated with Zataria multiflora essential oil and clove and cinnamon extracts showed higher antimicrobial efficacy compared with miconazole and clotrimazole. Formulations containing Uncaria tomentosa, Punica granatum, and propolis extract showed similar efficacy to nystatin and miconazole. Two formulations containing P. granatum were less effective than nystatin and miconazole. Gels of Z. multiflora and miconazole induced adverse effects including burning, itching, nausea, and vomiting. The included studies did not evaluate the biocompatibility of the gels.

CONCLUSIONS:

Gels formulated with natural antimicrobials such as Z. multiflora, U. tomentosa, P. granatum, propolis, and clove and cinnamon showed higher or similar antimicrobial efficacy to conventional antifungals in the treatment of DS. The biocompatibility of experimental gels based on natural agents should be evaluated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Systematic_reviews Idioma: En Revista: J Prosthet Dent Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Systematic_reviews Idioma: En Revista: J Prosthet Dent Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos