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Mechanism of cadmium-induced nephrotoxicity.
Bautista, Claudia J; Arango, Nidia; Plata, Consuelo; Mitre-Aguilar, Irma B; Trujillo, Joyce; Ramírez, Victoria.
Afiliação
  • Bautista CJ; Departamento de Biología de la Reproducción del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Ciudad de México 14080, Mexico.
  • Arango N; Departamento de Cirugía Experimental del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Ciudad de México 14080, Mexico.
  • Plata C; Departamento de Nefrología del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Ciudad de México 14080, Mexico.
  • Mitre-Aguilar IB; Unidad de Bioquímica del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Ciudad de México 14080, Mexico.
  • Trujillo J; Consejo Nacional de Humanidades, Ciencia y Tecnología, Instituto Potosino de Investigación Científica y Tecnológica A. C. División de Materiales Avanzados (CONAHCYT-IPICYT-DMA), San Luis Potosí, Mexico.
  • Ramírez V; Departamento de Cirugía Experimental del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Ciudad de México 14080, Mexico. Electronic address: victoria.ramirezg@incmnsz.mx.
Toxicology ; 502: 153726, 2024 02.
Article em En | MEDLINE | ID: mdl-38191021
ABSTRACT
Heavy metals are found naturally in our environment and have many uses and applications in daily life. However, high concentrations of metals may be a result of pollution due to industrialization. In particular, cadmium (Cd), a white metal abundantly distributed in the terrestrial crust, is found in mines together with zinc, which accumulates after volcanic eruption or is found naturally in the sea and earth. High levels of Cd have been associated with disease. In the human body, Cd accumulates in two ways via inhalation or consumption, mainly of plants or fish contaminated with high concentrations. Several international organizations have been working to establish the limit values of heavy metals in food, water, and the environment to avoid their toxic effects. Increased Cd levels may induce kidney, liver, or neurological diseases. Cd mainly accumulates in the kidney, causing renal disease in people exposed to moderate to high levels, which leads to the development of end-stage chronic kidney disease or death. The aim of this review is to provide an overview of Cd-induced nephrotoxicity, the mechanisms of Cd damage, and the current treatments used to reduce the toxic effects of Cd exposure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cádmio / Metais Pesados Limite: Animals / Humans Idioma: En Revista: Toxicology Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Irlanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cádmio / Metais Pesados Limite: Animals / Humans Idioma: En Revista: Toxicology Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Irlanda