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Leisure-Time Physical Activity May Attenuate the Impact of Diabetes on Cognitive Decline in Middle-Aged and Older Adults: Findings From the ELSA-Brasil Study.
Feter, Natan; de Paula, Danilo; Dos Reis, Rodrigo Citton P; Raichlen, David; Patrão, Ana Luísa; Barreto, Sandhi Maria; Suemoto, Claudia Kimie; Duncan, Bruce B; Schmidt, Maria Inês.
Afiliação
  • Feter N; Post Graduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
  • de Paula D; Post Graduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
  • Dos Reis RCP; Post Graduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
  • Raichlen D; Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA.
  • Patrão AL; Center for Psychology at University of Porto, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal.
  • Barreto SM; Deparment of Preventive and Social Medicine, Faculdade de Medicina and Clinical Hospital/Empresa Brasileira de Serviços Hospitalares, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Suemoto CK; Division of Geriatrics, University of São Paulo Medical School, São Paulo, Brazil.
  • Duncan BB; Post Graduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
  • Schmidt MI; Post Graduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Diabetes Care ; 47(3): 427-434, 2024 Mar 01.
Article em En | MEDLINE | ID: mdl-38181314
ABSTRACT

OBJECTIVE:

To assess leisure-time physical activity (LTPA) as a modifier of the diabetes/cognitive decline association in middle-aged and older participants in the Estudo Longitudinal de Saude do Adulto (ELSA-Brasil) study. RESEARCH DESIGN AND

METHODS:

ELSA-Brasil is a cohort of 15,105 participants (age 35-74 years) enrolled between 2008 and 2010. We evaluated global cognitive function, summing the scores of six standardized tests evaluating memory and verbal fluency, including the Trail-Making Test, at baseline and follow-up. Incident cognitive impairment was defined as a global cognitive function score at follow-up lower than -1 SD from baseline mean. Participants reporting ≥150 min/week of moderate to vigorous LTPA at baseline were classified as physically active. We assessed the association of LTPA with global cognition change in those with diabetes in the context of our overall sample through multivariable regression models.

RESULTS:

Participants' (N = 12,214) mean age at baseline was 51.4 (SD 8.8) years, and 55.5% were women. During a mean follow-up of 8.1 (SD 0.6) years, 9,345 (76.5%) inactive participants and 1,731 (14.1%) participants with diabetes at baseline experienced faster declines in global cognition than those who were active (ß = -0.003, -0.004, and -0.002) and those without diabetes (ß = -0.004, -0.005, and -0.003), respectively. Diabetes increased the risk of cognitive impairment (hazard ratio [HR] 1.71; 95% Cl 1.22, 2.39) in inactive but not in active adults (HR 1.18; 95% CI 0.73, 1.90). Among participants with diabetes, those who were active showed a delay of 2.73 (95% CI 0.94, 4.51) years in the onset of cognitive impairment.

CONCLUSIONS:

In adults living with diabetes, LTPA attenuated the deleterious association between diabetes and cognitive function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Diabetes Care Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Diabetes Care Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos