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Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis.
Pinto, Ana Carolina Matias Dinelly; de Melo Nunes, Rodolfo; de Freitas Carvalho, Waleska Vidal; Girão, Virgínia Claudia Carneiro; Rocha, Francisco Airton Castro.
Afiliação
  • Pinto ACMD; Programa de Pós-Graduação em Biotecnologia em Saúde Humana e Animal da Universidade Estadual do Ceará, Fortaleza - Ceará, Brazil.
  • de Melo Nunes R; Departamento de Medicina Interna da Faculdade de Medicina da Universidade Federal do Ceará, Fortaleza - Ceará, Brazil.
  • de Freitas Carvalho WV; Programa de Pós-Graduação em Biotecnologia em Saúde Humana e Animal da Universidade Estadual do Ceará, Fortaleza - Ceará, Brazil.
  • Girão VCC; Departamento de Morfologia da Faculdade de Medicina da Universidade Federal do Ceará, Fortaleza - Ceará, Brazil.
  • Rocha FAC; Departamento de Medicina Interna da Faculdade de Medicina da Universidade Federal do Ceará, Fortaleza - Ceará, Brazil. arocha@ufc.br.
Adv Rheumatol ; 64(1): 6, 2024 01 04.
Article em En | MEDLINE | ID: mdl-38178208
ABSTRACT

OBJECTIVE:

Despite some knowledge gaps in scientific evidence, MgCl2 is largely used for pain relief in musculoskeletal diseases. Mg salts were shown to provide analgesia postoperatively in orthopedic surgery and low Mg levels were linked to arthritis development and severity. We determined the anti-inflammatory activity of MgCl2 in an acute arthritis model.

METHODS:

Mice received 0.1 mg/25µL Zymosan (Zy) or saline into the knees. Joint pain was evaluated using von Frey test; cell influx, and interleukin (IL)-1 level were assessed in joint lavage at 6 h. Synovia were excised for histopathology and analysis of immunoexpression of nuclear factor kappa B (NFκB) and tumor necrosis factor (TNF)-α. Groups (n = 6/group) received either 90 mg/kg MgCl2/100 µL or saline per os (systemic) or 500 µg/25 µL MgCl2 or saline intra-articularly (i.a.) 30 min prior to Zy.

RESULTS:

MgCl2 given either systemically or locally significantly reduced cell influx (p = 0.0012 and p = 0.0269, respectively), pain (p = 0.0005 and p = 0.0038, respectively), and intra-articular IL-1 level (p = 0.0391), as compared to saline. Systemic MgCl2 significantly decreased NFκB (p < 0.05) immmunoexpression, as compared to saline.

CONCLUSION:

MgCl2 given systemically or locally displayed anti-inflammatory activity in a severe acute arthritis model reducing cell influx, pain, and cytokine release. MgCl2 operates at least partially via inhibiting NFκB activation. This is the first in vivo demonstration that MgCl2 decreases cytokine release in arthritis, prompting reduction of inflammation and pain relief.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Adv Rheumatol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Adv Rheumatol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido